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Semax Atomized Solution 30ml
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99%+ HPLC Purity — Independently verified by accredited US laboratory -
Endotoxin-Screened — LAL tested, LPS-free, endotoxin report available
-
GMP-Certified Manufacturing — USA facility, ISO 9001:2015
-
Lyophilized for Stability — Shipped cold-packed, intact for reconstitution
Molecular Weight
Third Party Tested
APPLICATION
For Research Use only
Form
Lyophilized Powder
Storage
-20°C Long Term
Purity (HPLC)
99%+ Third Party Verified
Manufacture
USA / GMP
4.9 847 verified reviews
Semax Atomized Solution 30ml
Total Price
$0.00
Discounted Price
$0.00
Packs
5 packs
You Save
$0.00
0% OFF
Select Strength (mg)
99% HPLC Purity
Select Packs
Bulk pricing applied
📈 Upgrade to 10 vials and save an extra vs. buying 5 — nearly 3 free vials.
Select Purchase Option:
-
99%+ HPLC Purity —
Independently verified by accredited US laboratory
-
Endotoxin-Screened —
LAL tested, LPS-free, endotoxin report available
-
GMP-Certified Manufacturing —
USA facility, ISO 9001:2015
-
Lyophilized for Stability —
Shipped cold-packed, intact for reconstitution
Molecular Weight
Third Party Tested
APPLICATION
For Research Use only
Form
Lyophilized Powder
Storage
-20°C Long Term
Purity (HPLC)
99%+ Third Party Verified
Manufacture
USA / GMP
Fill: 50mg per 30ml bottle · 1.67 mg/mL · metered valve, 250mcg per actuation · approx. 200 actuations per bottle
Semax Atomized Solution 30ml is supplied strictly for laboratory research use only. This material is intended for analytical and controlled research applications. It is not approved or intended for human or animal use, ingestion, dosing, or therapeutic application.
This product is not a nasal spray and is not manufactured, labeled, or offered for nasal or other human administration. It is not intended for ingestion, inhalation, injection, topical application, or introduction into the human or animal body by any route.
Semax is a synthetic peptide based on the ACTH(4–10) fragment. It is employed in laboratory studies as a tool compound for examining neurochemical signalling, gene-expression responses, and peptide–receptor interactions in controlled cell systems and animal models. Published in-vitro and preclinical literature has characterised its relationship to neurotrophic signalling pathways, including BDNF, TrkB, NGF, and GAP-43.
This formulation is manufactured as a High Purity, LPS-free peptide, supporting research environments that require minimised interference from bacterial contaminants. As an endotoxin-free peptide, it is suitable for sensitive in-vitro and analytical studies where endotoxin presence could compromise experimental integrity. All batches are research peptides endotoxin tested.
All references to Semax relate solely to research use, and no information here should be interpreted as guidance for human consumption, animal administration, or medical use.
This product is intended strictly for research and laboratory use only. Not for human or animal use. No statement on this page describes or implies any physiological, cosmetic, diagnostic, or therapeutic effect in humans or animals.
Semax at a glance
| Sequence | Met-Glu-His-Phe-Pro-Gly-Pro |
|---|---|
| Molecular formula | C₃₇H₅₁N₉O₁₀S |
| Molecular weight | 813.92 g/mol |
| CAS number | 80714-61-0 |
| Application | Research use only |
What is Semax?
Semax, a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) derived from the ACTH(4-10) fragment, is studied in laboratory and rodent models of neurotrophic signaling. Published work describes modulation of signaling pathways including BDNF, TrkB, NGF and GAP-43, and effects on neuronal plasticity, dopaminergic function and oxidative balance in animal central-nervous-system models.
How is Semax studied in the lab?
Study: Semax effects on intracellular calcium dynamics
In hippocampal and cerebellar slice models, Semax changed spontaneous intracellular calcium fluctuations in neurons providing insight into early cellular signaling events relevant to neuroprotection and synaptic plasticity.
Vascular and Neurotrophin Regulation in Ischemia
Study: Effects of Semax on VEGFA and related genes
After global ischemia in rats, Semax reduced ischemia-induced increases in vascular endothelial growth factor (VEGFA) mRNA, suggesting modulation of vascular responses and possible anti-inflammatory effects alongside neurotrophic support.
Study: Semax impacts neurotrophin and receptor expression after ischemia
Semax influenced mRNA levels of key neurotrophins (NGF, BDNF, NT-3) and their receptors, especially in cortex and hippocampus highlighting its role in adaptation of neurotrophin systems after brain injury.
What has preclinical research reported?
Neurotrophic Gene Expression and Cognitive Function
Study: Effect of Semax on BDNF and NGF gene expression in the rat brain
This research evaluated how Semax influences expression of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) key proteins involved in synaptic plasticity, learning, and memory. In the rat model, Semax altered gene-expression dynamics in hippocampus and frontal cortex.
Neuroprotection in Cerebral Ischemia (Stroke Models)
Study: Protective effects of Semax in rat cerebral ischemia-reperfusion
Using a transient middle cerebral artery occlusion (tMCAO) model, researchers found that Semax upregulated neuroprotective proteins (e.g., CREB) and downregulated inflammatory markers (e.g., MMP-9, JNK), suggesting molecular neuroprotection and reduced damage post-stroke.
Study: Gene expression changes in ischemic rat brain
A genome-wide study showed that Semax significantly modulated immune- and vascular-related gene expression after focal ischemia, implying immune and vascular system involvement in its neuroprotective effects.
Forms studied and handling
The material is supplied as a lyophilized (freeze-dried) powder. Freeze-drying is used for peptides because removing water suppresses the hydrolysis and aggregation routes that dominate degradation in solution, and the resulting amorphous solid is far more stable on storage than the corresponding liquid.5 Reported degradation routes for peptides in the solid state include deamidation of asparagine and glutamine residues, oxidation of methionine and tryptophan, and physical aggregation, all of which are accelerated by residual moisture, elevated temperature and repeated freeze-thaw cycling.6 Sealed vials are therefore held at −20 °C, protected from light, and reconstituted material is kept cold and used within a short working window. For laboratory research use only.
References
- Stavchanskiĭ, V. V., Tvorogova, T. V., Botsina, A. I.u, Skvortsova, V. I., Limborskaia, S. A., Miasoedov, N. F., & Dergunova, L. V. (2011). Molekuliarnaia biologiia, 45(6), 1026–1035. PMID 22295573
- Kolbaev, S. N., Sharonova, I. N., & Skrebitsky, V. G. (2025). The Effect of Peptide Semax, an ACTH(4-10) Analogue, on Intracellular Calcium Dynamics in Rat Brain Neurons. Bulletin of experimental biology and medicine, 179(4), 416–420. https://doi.org/10.1007/s10517-025-06501-z. PMID 41171324
- Medvedeva, E. V., Dmitrieva, V. G., Povarova, O. V., Limborska, S. A., Skvortsova, V. I., Myasoedov, N. F., & Dergunova, L. V. (2014). The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis. BMC genomics, 15, 228. https://doi.org/10.1186/1471-2164-15-228. PMID 24661604
- Agapova, T. I.u, Agniullin, I.aV., Silachev, D. N., Shadrina, M. I., Slominskiĭ, P. A., Shram, S. I., Limborskaia, S. A., & Miasoedov, N. F. (2008). Molekuliarnaia genetika, mikrobiologiia i virusologiia, (3), 28–32. PMID 18756821
- Wang W. Lyophilization and development of solid protein pharmaceuticals. International Journal of Pharmaceutics. 2000;203(1-2):1-60. doi:10.1016/S0378-5173(00)00423-3
- Manning MC, Chou DK, Murphy BM, et al. Stability of protein pharmaceuticals: an update. Pharmaceutical Research. 2010;27(4):544-575. doi:10.1007/s11095-009-0045-6
For laboratory research use only. Products on this website are intended solely for in-vitro research. They are not medicines, have not been evaluated by the FDA, and are not intended to diagnose, treat, cure, or prevent any disease. Any administration to humans or animals is strictly prohibited.
What are these peptides made for?
Our peptides are produced exclusively for laboratory and scientific research purposes.
Licensed Peptides™ products are developed using industry-standard synthesis and purification protocols, making them suitable for in vitro research, analytical testing, and experimental models.
Research-grade standards
- Synthesized via Solid Phase Peptide Synthesis (SPPS)
- Purified using advanced HPLC methods
- Verified through analytical quality control processes
- Screened for heavy metals and endotoxins
Consistency across batches
Strict process controls ensure reproducibility, allowing researchers to work with confidence across experiments.
Applications
Our peptides are commonly used in research involving:
- Cellular signaling pathways
- Tissue remodeling and repair mechanisms
- Extracellular matrix regulation
- Molecular biology and biochemical studies
All products are intended for research use only and are not for human or animal consumption, therapeutic use, or clinical application.
Why buy from Licensed Peptides
At Licensed Peptides™, quality isn’t a claim — it’s a controlled, repeatable process.
Every peptide we produce follows a strict, pharma-grade workflow designed to ensure purity, stability, and consistency from synthesis to delivery.
What sets us apart
ISO-certified cleanroom manufacturing
All peptides are synthesized in sterile, controlled environments to eliminate contamination risk and ensure batch consistency.
>99% verified purity (HPLC tested)
We use advanced High-Performance Liquid Chromatography (HPLC) to separate and verify peptide purity with precision.
Comprehensive safety testing
Each batch undergoes heavy metal and endotoxin screening to ensure it is free from hidden contaminants.
Pharma-grade raw materials
We start with rigorously tested amino acids and reagents, ensuring integrity at the molecular level.
Lyophilized for stability
Freeze-dried peptides maintain long-term stability, potency, and reliability for research applications.
Nitrogen-sealed vials
Every vial is protected from oxygen and moisture, preserving structural integrity during storage and transit.
Built for serious research
From synthesis to delivery, every step is engineered to meet the expectations of professionals who require accuracy, consistency, and reliability.
For laboratory research use only. Not for human or veterinary use.
How orders ship
We understand that timing and product integrity are critical for research.
| Ships to | United States (including minor outlying islands) |
|---|---|
| Processing days | Monday to Friday, excluding holidays |
| Daily cut-off | Paid orders placed before 4:00 PM PST are typically shipped the same business day |
| Free shipping | FedEx 2-Day Express on orders over $200 and for VIP members |
| Standard | USPS Ground Advantage, 3–7 business days (not guaranteed) — $8.95 |
| Expedited | FedEx 2-Day $11.95 · UPS 2-Day $19.95 · FedEx Next Day $44.99 |
| Signature | Required on delivery for orders of $1,000 or more |
How orders are handled
Cold chain protection
Products are stored in industrial-grade freezers prior to shipment to maintain stability and purity.
Secure & protective packaging
Each order is carefully packed to protect against temperature fluctuations, moisture exposure, and physical damage during transit.
Tracking
Once your order has shipped you will receive a tracking number by email, so you can monitor delivery progress.
Shipped from the United States
Orders are dispatched domestically from a U.S.-based operation, so there are no international customs steps.
Delivery times
Shipping times are estimates and begin after order processing. Delays may occur due to carrier issues, weather, or other unforeseen factors, and delivery dates are not guaranteed. Full terms are in our Shipping & Delivery Policy.
For laboratory research use only. Not for human or veterinary use.
Additional information
| pack | 1 pack, 3 pack, 5 pack, 10 pack |
|---|
Storage
Store in the original container in a refrigerator at 2–8°C (36–46°F). Keep tightly closed when not in use. Protect from light, heat, and moisture. Do not freeze.
Handling Precautions
Avoid excessive shaking or agitation. Keep the actuator clean and replace the cap immediately after each use to prevent contamination.
Stability
Utilize within the recommended timeframe after opening (commonly 30–60 days, depending on formulation and preservatives).
99%+ — Passes ≥99% 
Download Full COA / HPLC Report (PDF) 
99%+ Every Batch
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