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TB-500 (Thymosin Beta-4) · 10mg
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$584.95
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10 vials
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99%+ HPLC Purity — Independently verified by accredited US laboratory -
Endotoxin-Screened — LAL tested, LPS-free, endotoxin report available
-
GMP-Certified Manufacturing — USA facility, ISO 9001:2015
-
Lyophilized for Stability — Shipped cold-packed, intact for reconstitution
Molecular Weight
Third Party Tested
APPLICATION
For Research Use only
Form
Lyophilized Powder
Storage
-20°C Long Term
Purity (HPLC)
99%+ Third Party Verified
Manufacture
USA / GMP
4.9 847 verified reviews
TB-500 (Thymosin Beta-4) · 10mg
Total Price
$1,044.56
Discounted Price
$584.95
Vials
10 vials
You Save
$459.61
44% OFF
Select Strength (mg)
99% HPLC Purity
Select Vials
Bulk pricing applied
📈 Upgrade to 10 vials and save an extra vs. buying 5 — nearly 3 free vials.
Select Purchase Option:
-
99%+ HPLC Purity —
Independently verified by accredited US laboratory
-
Endotoxin-Screened —
LAL tested, LPS-free, endotoxin report available
-
GMP-Certified Manufacturing —
USA facility, ISO 9001:2015
-
Lyophilized for Stability —
Shipped cold-packed, intact for reconstitution
Molecular Weight
Third Party Tested
APPLICATION
For Research Use only
Form
Lyophilized Powder
Storage
-20°C Long Term
Purity (HPLC)
99%+ Third Party Verified
Manufacture
USA / GMP
TB-500 (Thymosin Beta-4) 10mg is a laboratory research peptide used to study actin-related signaling, cellular migration, and experimental pathway responses in controlled systems. This product is supplied strictly for research use only. It is not approved or intended for human or animal use, and any discussion of biological activity refers only to preclinical or in vitro research
TB-500 supplied for research applications is manufactured as a high purity, LPS-free peptide and is classified as an endotoxin-free peptide, ensuring minimal interference in sensitive experimental systems. Each batch is produced under stringent quality controls and is research peptides endotoxin tested, supporting reproducibility and reliability in in-vitro and preclinical study designs.
This material is intended strictly for laboratory research and scientific investigation only. TB-500 is not intended for human or animal use, and no information herein should be interpreted as relating to therapeutic application, clinical outcomes, or direct biological benefit outside of controlled research settings.
TB-500 (Thymosin Beta-4) at a glance
| Molecular formula | C₂₁₂H₃₅₀N₅₆O₇₈S |
|---|---|
| CAS number | 77591-33-4 |
| PubChem CID | 16132341 |
| Form supplied | Lyophilized powder |
| Application | Research use only |
What is TB-500 (Thymosin Beta-4)?
TB-500 is a laboratory research material used to examine peptide behavior, cytoskeletal interactions, and cellular-response pathways in controlled experimental models. References to biological effects are provided for scientific context only and must not be interpreted as claims of therapeutic, diagnostic, or clinical benefit. This product is not offered for human or veterinary use.
TB-500 is a synthetic peptide corresponding to the actin-binding region of thymosin beta-4, a 43-amino-acid, intrinsically disordered protein. The relevant chemistry is the actin-binding motif itself: thymosin beta-4 binds monomeric G-actin in a 1:1 complex and holds it out of the polymerisation pool.4
How is TB-500 (Thymosin Beta-4) studied in the lab?
TB-500 is used in laboratory studies involving actin-binding behavior, cytoskeletal organization, and cellular-response analysis. Any references to tissue remodeling or oxidative-stress pathways are provided only for research context and do not imply therapeutic or clinical use.
Published work uses cell-free actin polymerisation assays, cultured endothelial and epithelial cells for migration readouts, and rodent models with histological endpoints; cardiac work used embryonic and adult mouse tissue with cell-migration and survival measurements.4, 5, 6
What has preclinical research reported?
TB-500 in Research Settings
In laboratory research, TB-500 is examined for its interaction with actin-related pathways and downstream cellular responses. Studies may focus on membrane behavior, cell movement, and experimental model development in controlled research environments. These references are included solely for scientific context and should not be interpreted as claims of medical benefit.
Key Research Areas Involving TB-500
TB-500 is used in experimental research investigating:
- actin regulation
- cellular migration
- tissue-structure analysis
- angiogenesis-related signaling
- oxidative-stress pathway research
- assay development
All references to biological pathways are provided for research context only and do not imply human or veterinary applications
TB-500 (Thymosin Beta) : Research
TB-500 is used in laboratory studies to examine actin-binding behavior, cell-migration pathways, and tissue-structure responses under controlled experimental conditions. Any references to research models are provided only for context and do not imply therapeutic, diagnostic, or clinical use.
Actin sequestration (cell-free)
Thymosin beta-4 is characterised as the principal actin-sequestering protein in many cell types, forming a 1:1 complex with G-actin; this is the molecular basis for the synthetic fragment.4
Endothelial and epithelial migration (in vitro and rodent)
Thymosin beta-4 was reported to accelerate wound closure in rodent models and to increase keratinocyte and endothelial cell migration in culture.5
Integrin-linked kinase signalling (mouse cardiac cells)
In mouse cardiac cells, thymosin beta-4 was reported to activate integrin-linked kinase and to promote cell migration and survival.6
Forms studied and handling
Supplied as a lyophilised powder in a sealed vial. Published handling practice for research peptides of this class is cold, dry, light-protected storage of the lyophilised solid, with reconstituted material kept refrigerated and used within the stability window established by the laboratory. For laboratory research use only.
References
- Malinda KM, Sidhu GS, Mani H, Banaudha K, Maheshwari RK, Goldstein AL, Kleinman HK. Thymosin beta4 accelerates wound healing. J Invest Dermatol. 1999 Sep;113(3):364-8. doi: 10.1046/j.1523-1747.1999.00708.x. PMID: 10469335. PMID 10469335
- Philp D, Badamchian M, Scheremeta B, Nguyen M, Goldstein AL, Kleinman HK. Thymosin beta 4 and a synthetic peptide containing its actin-binding domain promote dermal wound repair in db/db diabetic mice and in aged mice. Wound Repair Regen. 2003 Jan-Feb;11(1):19-24. doi: 10.1046/j.1524-475x.2003.11105.x. PMID: 12581423. PMID 12581423
- Peng H, Xu J, Yang XP, Dai X, Peterson EL, Carretero OA, Rhaleb NE. Thymosin-β4 prevents cardiac rupture and improves cardiac function in mice with myocardial infarction. Am J Physiol Heart Circ Physiol. 2014 Sep 1;307(5):H741-51. doi: 10.1152/ajpheart.00129.2014. Epub 2014 Jul 11. PMID: 25015963; PMCID: PMC4187393. PMID 25015963
- Goldstein AL, Hannappel E, Kleinman HK. Thymosin beta-4: actin-sequestering protein moonlights to repair injured tissues. Trends Mol Med. 2005;11(9):421-429. doi:10.1016/j.molmed.2005.07.004
- Malinda KM, Kleinman HK, Sidhu GS, et al. Thymosin beta-4 accelerates wound healing. J Invest Dermatol. 1999;113(3):364-368. doi:10.1046/j.1523-1747.1999.00708.x
- Bock-Marquette I, Saxena A, White MD, et al. Thymosin beta-4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair. Nature. 2004;432(7016):466-472. doi:10.1038/nature03000
For laboratory research use only. Products on this website are intended solely for in-vitro research. They are not medicines, have not been evaluated by the FDA, and are not intended to diagnose, treat, cure, or prevent any disease. Any administration to humans or animals is strictly prohibited.
What are these peptides made for?
Our peptides are produced exclusively for laboratory and scientific research purposes.
Licensed Peptides™ products are developed using industry-standard synthesis and purification protocols, making them suitable for in vitro research, analytical testing, and experimental models.
Research-grade standards
- Synthesized via Solid Phase Peptide Synthesis (SPPS)
- Purified using advanced HPLC methods
- Verified through analytical quality control processes
- Screened for heavy metals and endotoxins
Consistency across batches
Strict process controls ensure reproducibility, allowing researchers to work with confidence across experiments.
Applications
Our peptides are commonly used in research involving:
- Cellular signaling pathways
- Tissue remodeling and repair mechanisms
- Extracellular matrix regulation
- Molecular biology and biochemical studies
All products are intended for research use only and are not for human or animal consumption, therapeutic use, or clinical application.
Why buy from Licensed Peptides
At Licensed Peptides™, quality isn’t a claim — it’s a controlled, repeatable process.
Every peptide we produce follows a strict, pharma-grade workflow designed to ensure purity, stability, and consistency from synthesis to delivery.
What sets us apart
ISO-certified cleanroom manufacturing
All peptides are synthesized in sterile, controlled environments to eliminate contamination risk and ensure batch consistency.
>99% verified purity (HPLC tested)
We use advanced High-Performance Liquid Chromatography (HPLC) to separate and verify peptide purity with precision.
Comprehensive safety testing
Each batch undergoes heavy metal and endotoxin screening to ensure it is free from hidden contaminants.
Pharma-grade raw materials
We start with rigorously tested amino acids and reagents, ensuring integrity at the molecular level.
Lyophilized for stability
Freeze-dried peptides maintain long-term stability, potency, and reliability for research applications.
Nitrogen-sealed vials
Every vial is protected from oxygen and moisture, preserving structural integrity during storage and transit.
Built for serious research
From synthesis to delivery, every step is engineered to meet the expectations of professionals who require accuracy, consistency, and reliability.
For laboratory research use only. Not for human or veterinary use.
How orders ship
We understand that timing and product integrity are critical for research.
| Ships to | United States (including minor outlying islands) |
|---|---|
| Processing days | Monday to Friday, excluding holidays |
| Daily cut-off | Paid orders placed before 4:00 PM PST are typically shipped the same business day |
| Free shipping | FedEx 2-Day Express on orders over $200 and for VIP members |
| Standard | USPS Ground Advantage, 3–7 business days (not guaranteed) — $8.95 |
| Expedited | FedEx 2-Day $11.95 · UPS 2-Day $19.95 · FedEx Next Day $44.99 |
| Signature | Required on delivery for orders of $1,000 or more |
How orders are handled
Cold chain protection
Products are stored in industrial-grade freezers prior to shipment to maintain stability and purity.
Secure & protective packaging
Each order is carefully packed to protect against temperature fluctuations, moisture exposure, and physical damage during transit.
Tracking
Once your order has shipped you will receive a tracking number by email, so you can monitor delivery progress.
Shipped from the United States
Orders are dispatched domestically from a U.S.-based operation, so there are no international customs steps.
Delivery times
Shipping times are estimates and begin after order processing. Delays may occur due to carrier issues, weather, or other unforeseen factors, and delivery dates are not guaranteed. Full terms are in our Shipping & Delivery Policy.
For laboratory research use only. Not for human or veterinary use.
Additional information
| pack | 1 pack, 3 pack, 5 pack, 10 pack |
|---|
Storage conditions at a glance
| Lyophilized, in transit | Stable for shipping for up to 3–4 months |
|---|---|
| Lyophilized, short term | Room temperature is usually adequate for several weeks; refrigeration under 4°C (39°F) is generally acceptable |
| Lyophilized, long term | Freezer at -80°C (-112°F) for several months to years |
| After reconstitution | Refrigerated; stable for up to 30 days |
| Light and moisture | Keep cold and away from light in the original sealed vial |
Why the powder is stable
All of our products are manufactured using the lyophilization (freeze drying) process, which keeps them stable for shipping for up to 3–4 months.
Lyophilization is a unique dehydration process, also known as cryodesiccation, where the peptides are frozen and then subjected to low pressure. This causes the water in the peptide vial to sublimate directly from solid to gas, leaving behind a stable, crystalline white structure known as lyophilized peptide. The puffy white powder can be stored at room temperature until it is reconstituted with bacteriostatic water.
Storing vials on arrival
Once peptides have been received, it is imperative that they are kept cold and away from light. If the peptides will be used in the next several days, weeks or months, short-term refrigeration under 4°C (39°F) is generally acceptable. Lyophilized peptides are usually stable at room temperatures for several weeks or more, so if they will be utilized within weeks or months such storage is typically adequate.
For longer term storage (several months to years) it is more preferable to store peptides in a freezer at -80°C (-112°F). When storing peptides for months or even years, freezing is optimal in order to preserve the peptide’s stability.
After reconstitution
Once the peptides are reconstituted with bacteriostatic water, they must be stored in the fridge to maintain stability. After reconstitution, the peptides will remain stable for up to 30 days.
For laboratory research use only. Not for human or veterinary use.
99%+ — Passes ≥99% 
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99%+ Every Batch
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