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5-Amino-1MQ · 5mg
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Lyophilized for Stability — Shipped cold-packed, intact for reconstitution
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Third Party Tested
APPLICATION
For Research Use only
Form
Lyophilized Powder
Storage
-20°C Long Term
Purity (HPLC)
99%+ Third Party Verified
Manufacture
USA / GMP
4.9 847 verified reviews
5-Amino-1MQ · 5mg
Total Price
$344.93
Discounted Price
$241.45
Vials
5 vials
You Save
$103.48
30% OFF
Select Vials
Bulk pricing applied
📈 Upgrade to 10 vials and save an extra vs. buying 5 — nearly 3 free vials.
Select Purchase Option:
-
99%+ HPLC Purity —
Independently verified by accredited US laboratory
-
Endotoxin-Screened —
LAL tested, LPS-free, endotoxin report available
-
GMP-Certified Manufacturing —
USA facility, ISO 9001:2015
-
Lyophilized for Stability —
Shipped cold-packed, intact for reconstitution
Molecular Weight
Third Party Tested
APPLICATION
For Research Use only
Form
Lyophilized Powder
Storage
-20°C Long Term
Purity (HPLC)
99%+ Third Party Verified
Manufacture
USA / GMP
What Is 5-Amino-1MQ?
5-Amino-1MQ is a common abbreviation for 5-amino-1-methylquinolinium. It’s a small-molecule research compound investigated in studies involving Nicotinamide N-Methyltransferase (NNMT). Unlike peptides, 5-Amino-1MQ belongs to the methylquinolinium class of compounds. It’s studied as a selective NNMT inhibitor in laboratory settings.
NNMT is an enzyme that catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to nicotinamide (NAM), producing 1-methylnicotinamide (MNA) and S-adenosylhomocysteine (SAH). NNMT participates in nicotinamide metabolism through this activity. It may influence cellular methylation balance, metabolic signaling, and NAD⁺-related biochemical pathways.
Why Researchers Study 5-Amino-1MQ
Scientific interest in 5-Amino-1MQ comes from the research into NNMT biology and its contribution to cellular metabolism.
Published studies have investigated NNMT and NNMT inhibitors across areas of laboratory and preclinical research, including
- Nicotinamide metabolism
- NNMT pathway regulation
- Cellular energy metabolism
- NAD+ salvage-pathway biology
- Adipocyte biology
- Molecular signaling pathways
- Methylation-related biochemical processes
- Experimental metabolic research models
NNMT influences multiple interconnected biochemical pathways. Researchers investigate how selective NNMT inhibition affects cellular processes under controlled laboratory conditions.
Key Published Research
A widely cited study by Kraus and colleagues used genetic knockdown in mice. They investigated the biological role of NNMT. The researchers reported that lowering NNMT expression changed metabolic pathway activity and energy use. This helped to show that NNMT is a key target in metabolic research.¹
Neelakantan and colleagues then expanded research involving small-molecule NNMT inhibitors. Their work found and described several selective NNMT inhibitors, including 5-amino-1-methylquinolinium derivatives. They tested these inhibitors in cell and animal models.² They reported changes in intracellular nicotinamide-related metabolites and examined the biological effects of NNMT inhibition under experimental conditions.²
These outcomes have increased scientific interest in NNMT biology. They still support lab studies on its role in cell metabolism. They also support research on biochemical regulation.
Research Considerations And Limitations
Current evidence involving 5-Amino-1MQ and NNMT inhibition is predominantly preclinical. Most published findings originate from cell-based studies and animal models.
Although NNMT may affect nicotinamide levels and NAD+ pathways, the real impact in the body is still unclear. Research is ongoing. Changes in NNMT activity shouldn’t be interpreted as producing predictable changes in NAD+ levels across all biological systems.
Human safety, efficacy, dosing, and clinical utility haven’t been established. Further research is required to characterize the biological mechanisms associated with NNMT inhibition and the broader implications of these findings.
Licensed Peptides supplies 5-Amino-1MQ strictly for laboratory research purposes. It isn’t approved for human or animal use.
References
- Kraus D, Yang Q, Kong D, et al. Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. Nature. 2014;508(7495):258-262. doi:10.1038/nature13198.
- Neelakantan H, Vance V, Wetzel MD, et al. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice. Biochemical Pharmacology. 2018;147:141-152.
- Aksoy S, Szumlanski CL, Weinshilboum RM. Human nicotinamide N-methyltransferase. Pharmacogenetics. 1994;4(2):81-86.
- Alston TA, Abeles RH. Substrate specificity and catalytic mechanism of nicotinamide N-methyltransferase. Archives of Biochemistry and Biophysics. 1988;260(2):601-608.
- Gao Y, Martin NI, van Haren MJ. Nicotinamide N-Methyltransferase: At the crossroads of metabolism and epigenetic regulation. Trends in Biochemical Sciences. 2024.
Important Notice
This product is supplied strictly for research use only. It is not approved or intended for human or animal use, consumption, therapeutic use, clinical application, or diagnostic purposes. Any discussion of biological activity refers solely to laboratory, in vitro, or preclinical research.
Overview
5-Amino-1MQ is a laboratory research material used to study NNMT-related metabolic pathways, nicotinamide handling, NAD+ homeostasis, and cellular energy regulation in controlled experimental systems. References to metabolic activity are limited to nonclinical research context only. This product is not offered for diagnosis, treatment, prevention, or any human or veterinary use.
5-Amino-1 MQ: Structure
Molecular Formula: C₁₀H₁₁N₂
Molecular Weight: 159.21 g/mol
PubChem CID: 950107
CAS Number: 42464-96-0
Synonyms: 5-amino-1-methylquinolinium
Source: PubChem
Mechanistic Background
NNMT catalyzes the methylation of nicotinamide, a key precursor in the NAD+ salvage pathway. Increased NNMT activity has been observed in several metabolic research models and is associated with altered energy expenditure and disrupted NAD+ recycling.
5-Amino-1MQ functions as an NNMT inhibitor in experimental environments. By reducing NNMT catalytic activity, the compound allows researchers to evaluate how limiting nicotinamide methylation influences:
- NAD+ availability
- Cellular redox balance
- Mitochondrial efficiency
- Lipid storage and mobilization pathways
In vitro and in vivo experimental models (non-clinical, non-human) have demonstrated that NNMT suppression leads to measurable changes in cellular energy markers and adipocyte behavior. These findings have positioned 5-Amino-1MQ as a useful molecular tool for probing upstream metabolic regulation.
Key Research Attributes
- Highly specific NNMT inhibition profile
- Small-molecule stability and consistency
- Suitable for metabolic and enzymatic pathway modeling
- Compatible with NAD+-focused experimental designs
- Non-hormonal mechanism of action
Research Applications
5-Amino-1MQ may be used in laboratory studies involving:
- NNMT inhibition research
- Nicotinamide metabolism
- NAD+ pathway exploration
- Cellular redox balance
- Mitochondrial function modeling
- Adipocyte biology in experimental systems
- Metabolic signaling research
All applications are limited to research settings only and do not imply any approved human or animal use.
Product Specifications
- Compound: 5-Amino-1MQ
- Quantity: 5 mg per vial
- Form: Lyophilized powder
- Purity: Research-grade, high-purity standard
- Use Classification: Research use only
Each vial is prepared to support precise measurement and repeatable experimental outcomes in controlled laboratory environments.
Storage and Handling (Research Context)
- Store in a cool, dry location away from direct light
- Maintain appropriate laboratory storage protocols
- Reconstituted material should be handled under sterile research conditions
- Stability is preserved when stored according to standard laboratory guidelines
Commitment to Research Standards
Licensed Peptides supplies 5-Amino-1MQ strictly for investigative and research purposes. All products are prepared and packaged to meet laboratory expectations, ensuring consistency, stability, and accurate compound identification. No claims are made regarding therapeutic, diagnostic, or biological suitability beyond research use.
Frequently Asked Questions (Research Context)
What is 5-Amino-1MQ?
5-Amino-1MQ is used by researchers as a tool to study NNMT inhibition and downstream cellular pathways in controlled laboratory models. It is supplied strictly for research use only and is not approved for human or animal administration.
Is 5-Amino-1MQ approved for human or animal use?
No. It is strictly designated for laboratory research only and is not approved for human or animal administration.
What types of studies commonly use 5-Amino-1MQ?
Metabolic pathway research, adipocyte behavior studies, mitochondrial efficiency analysis, and NAD+-related biochemical investigations.
Can this compound be combined with other research materials?
In laboratory studies, it is sometimes used alongside other metabolic or mitochondrial research agents, depending on experimental design.
How stable is 5-Amino-1MQ in laboratory storage?
The lyophilized form demonstrates strong stability when stored correctly under standard laboratory conditions.
What makes 5-Amino-1MQ distinct from NAD+ precursor compounds in research?
Rather than supplying additional precursors, it limits NAD+ depletion by inhibiting NNMT, allowing exploration of upstream metabolic control.
Is this compound considered hormonal or endocrine-active?
No. Available research indicates it operates through enzymatic modulation rather than hormonal pathways.
Why is the 5 mg format commonly used in research?
It provides sufficient material for multiple experimental runs while minimizing waste and supporting precise measurement.
Is 5-Amino-1MQ 5 mg suitable for cell-based research applications?
Yes. The compound is produced as an LPS-free and endotoxin-free research peptide, making it suitable for controlled in vitro and experimental laboratory studies where endotoxin interference must be minimized.
How is endotoxin quality verified for this product?
Each batch of 5-Amino-1MQ is research peptides endotoxin tested, ensuring compliance with laboratory standards for purity and contamination control prior to research use.
What level of purity can researchers expect from this compound?
5-Amino-1MQ 5 mg is supplied as a high-purity research compound, designed to provide consistent and reliable performance across experimental models investigating NNMT-related pathways.
5-AMINO – 1MQ: Research
Scientific Background
Published laboratory studies have examined 5-Amino-1MQ as an NNMT inhibitor in experimental models. The compound is used to investigate nicotinamide metabolism, NAD+ regulation, and related metabolic pathways under controlled research conditions. Any references to obesity, glucose regulation, adiposity, liver function, or related biological outcomes are for research context only and must not be interpreted as medical, therapeutic, or clinical claims.
Referenced Citations
ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.
The products available on this website are intended solely for in-vitro research purposes (Latin: “in glass”), meaning they are used in experiments conducted outside a living organism. These products are not medicines or drugs, have not been evaluated or approved by the U.S. Food and Drug Administration (FDA), and are not intended to diagnose, treat, cure, or prevent any disease or medical condition. Any administration to humans or animals, whether by ingestion, injection, or other means, is strictly prohibited by law.
Storage And Handling Information
Proper storage conditions help preserve the integrity, stability, and analytical consistency of 5-Amino-1MQ throughout laboratory handling and long-term storage.
Understanding The Lyophilized Format
5-Amino-1MQ is supplied in a lyophilized (freeze-dried) form to support stability during transportation and storage. Lyophilization is a specialized preservation process. It removes water under controlled low temperature and low-pressure conditions. This leaves a stable, dry compound that is suitable for research applications.
This approach helps reduce degradation during shipping and allows the material to maintain its quality under appropriate storage conditions.
Short-Term Storage
For near-term laboratory use, lyophilized 5-Amino-1MQ should be kept in a cool, dry environment protected from direct light, excessive heat, and moisture exposure.
Refrigerated storage below 4°C (39°F) is generally appropriate for short-term preservation when the material will be utilized within weeks or months of receipt.
Long-Term Storage
For extended storage periods, we recommend freezer conditions to maintain long-term stability.
Researchers storing 5-Amino-1MQ for several months or longer may consider deep-freeze storage at approximately -80°C (-112°F) when consistent long-term preservation is required.
Handling Considerations
To minimize environmental exposure, containers should remain tightly sealed when not in use and handled according to established laboratory protocols. Maintaining stable storage conditions can help support consistency across analytical and experimental workflows.
For additional handling recommendations and laboratory best practices, please refer to our Peptide Storage Guide.
At Licensed Peptides™, we integrate quality assurance into every stage of manufacturing and testing.
Each batch of 5-Amino-1MQ undergoes rigorous analytical verification designed to support reproducibility and consistency in laboratory environments.
• Quality-Control Measures
• High-Performance Liquid Chromatography (HPLC) purity verification
• Identity confirmation through analytical testing
• Batch-specific quality documentation
• Comprehensive manufacturing controls
• Independent third-party verification procedures
Researchers seeking reliable analytical materials often prioritize consistency and documented quality-control procedures. Licensed Peptides supports these requirements through batch-specific testing and accessible quality documentation.
Researchers seeking 5 Amino 1MQ for sale should prioritize analytical verification, batch-specific Certificates of Analysis (COAs), and documented quality-control procedures when evaluating research suppliers. The quality of a research compound depends not only on purity specifications but also on manufacturing controls, testing standards, and traceability.
At Licensed Peptides™, every batch of 5-Amino-1MQ undergoes analytical testing designed to verify compound identity, purity, and consistency before release. From manufacturing and quality control through to packaging and fulfillment, our processes are structured to support reliable laboratory research.
What sets us apart:
ISO-Certified Manufacturing Environments
5-Amino-1MQ is produced under controlled manufacturing conditions designed to promote consistency across production lots and reduce variability between batches.
99%+ Verified Purity
Each batch undergoes analytical testing to verify purity specifications and support reproducible laboratory research.
Comprehensive Quality-Control Screening
Products are evaluated according to established quality-control procedures before release, helping ensure consistency, identity verification, and batch traceability.
Research-Grade Raw Materials
Manufacturing begins with carefully sourced starting materials selected to meet strict quality standards for research applications.
Lyophilized For Stability
The lyophilized format supports storage stability, laboratory handling, and long-term preservation under appropriate conditions.
Protective Packaging Standards
Products are packaged using controlled processes designed to help maintain compound integrity during storage and transit.
Batch-Specific Documentation
Every lot is supported by batch-specific Certificates of Analysis, providing researchers with transparent access to testing and verification data.
Shipping And Documentation
Reliable fulfillment is an important component of research planning. Licensed Peptides maintains domestic inventory and fulfillment operations to support efficient delivery and product integrity throughout the shipping process.
Domestic Fulfillment
We process and dispatch orders from within the United States. We typically prepare in-stock products submitted before the daily shipping cutoff (4 PM PST) for carrier collection the same business day.
Expedited Delivery Network
We work with established shipping partners to facilitate efficient nationwide delivery. Most domestic orders arrive within standard expedited transit windows, depending on destination and carrier routing.
Controlled Storage Before Dispatch
All research compounds are stored under appropriate storage conditions before shipment. Inventory is stored in monitored environments designed to preserve product quality and batch consistency until fulfillment occurs.
Protective Packaging Standards
We package every shipment to reduce the risk of environmental exposure during transit. We choose packaging materials to protect against handling-related damage, moisture exposure, and transportation stress.
Shipment Visibility
We provide tracking information once an order enters the carrier network, allowing researchers to monitor shipment progress and estimated delivery timelines.
Documentation and Quality Assurance
Orders are supported by batch-specific quality documentation, including Certificates of Analysis where applicable. This provides transparency regarding product identity, testing, and verification standards.
Developed Around Research Reliability
Our fulfillment process supports laboratories, researchers, and analytical facilities that require dependable access to research materials without unnecessary shipping delays or fulfillment uncertainty.
Additional information
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