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For Research Use only
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Lyophilized Powder
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-20°C Long Term
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99%+ Third Party Verified
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USA / GMP
4.9 847 verified reviews
Cagrilintide
Total Price
$539.93
Discounted Price
$377.95
Vials
5 vials
You Save
$161.98
30% OFF
Select Strength (mg)
99% HPLC Purity
Select Vials
Bulk pricing applied
📈 Upgrade to 10 vials and save an extra vs. buying 5 — nearly 3 free vials.
Select Purchase Option:
-
99%+ HPLC Purity —
Independently verified by accredited US laboratory
-
Endotoxin-Screened —
LAL tested, LPS-free, endotoxin report available
-
GMP-Certified Manufacturing —
USA facility, ISO 9001:2015
-
Lyophilized for Stability —
Shipped cold-packed, intact for reconstitution
Molecular Weight
Third Party Tested
APPLICATION
For Research Use only
Form
Lyophilized Powder
Storage
-20°C Long Term
Purity (HPLC)
99%+ Third Party Verified
Manufacture
USA / GMP
Cagrilintide is a long-acting amylin analogue currently under investigation for its potential roles in metabolic research. As a synthetic peptide modeled after the naturally occurring hormone amylin, co-secreted with insulin, Cagrilintide has demonstrated noteworthy effects in animal studies and controlled research environments. These findings have prompted increasing scientific interest in its interaction with appetite regulation pathways, metabolic signaling, and energy expenditure. While the molecule remains investigational, early data indicate that its mechanistic profile may offer multiple avenues for future study.
Within experimental environments, Cagrilintide has been explored for its receptor activity, downstream signaling effects, and stability profile relative to native amylin. Research observations suggest that its extended duration of action and receptor engagement characteristics may offer multiple avenues for further mechanistic investigation. Ongoing studies continue to evaluate its role in metabolic signaling networks, peptide-receptor dynamics, and neuroendocrine communication pathways under controlled conditions.
Cagrilintide supplied for research purposes is manufactured as a high-purity, LPS-free peptide and is endotoxin-free, ensuring suitability for sensitive laboratory applications. Each batch is produced under stringent quality controls and is research peptide endotoxin tested, supporting reproducibility and reliability in experimental settings where contaminant interference must be minimized.
All information provided herein relates exclusively to laboratory, preclinical, or controlled research settings. Cagrilintide is not for human or animal consumption, not for therapeutic use, and is not intended to diagnose, treat, cure, or prevent any disease or condition. Its availability is strictly limited to qualified research use.
Cagrilintide Overview:
Cagrilintide is a long-acting amylin analogue used in laboratory research to study receptor signaling, peptide stability, and related experimental models of metabolic biology. References to biological activity on this page are provided for research context only and must not be interpreted as claims of therapeutic, diagnostic, or clinical benefit. This product is supplied strictly for research use only and is not intended for human or animal use.
Research Context
In controlled laboratory settings, cagrilintide may be used to investigate amylin-receptor activity, peptide-receptor interactions, and downstream signaling pathways. Any references to appetite signaling, energy expenditure, satiety, or food intake are limited to experimental research context only and do not imply approved human or veterinary use.
Key Areas of Research Interest
Studies to date have explored its potential applications in the following areas:
- Amylin-receptor signaling research
- Peptide stability studies
- Downstream pathway analysis
- Ligand-receptor interaction studies
- Experimental endocrine pathway modeling
- Neuroendocrine signaling research
This material is provided for laboratory research only and is not intended for diagnosis, treatment, prevention, or consumption.
Cagrilintide: Structure
Molecular formula: C₁₉₁H₂₉₄N₅₂O₅₈S₂
Molecular weight: ~ 4226.8 g/mol
Peptide length: 37 amino acids
Disulfide bonds: 1 (between Cys² and Cys⁷)
Modification: Lipidation at Lys²⁸ via γ-glutamic acid linker and C16 fatty diacid
Type: Long-acting amylin analogue (peptide drug)
Half-life: ~8 days (due to lipidation and albumin binding)
Source: PubChem
How It Works – Research Mechanism of Action
In scientific terms, Cagrilintide’s function begins with its activation of amylin receptors, including the calcitonin receptor complexes found in brain regions tied to appetite monitoring. These interactions have been observed to produce:
- Reduced food-intake behavior
- Altered reward-related feeding signals
- Enhanced satiety cues
- Modulated metabolic rhythms
Again, these outcomes pertain to research subjects only, forming the basis of experimental inquiry into metabolic regulation.
Appropriate Research Contexts for Cagrilintide
Cagrilintide may be relevant for laboratories or investigators who study:
- Appetite signaling mechanisms
- Overeating and reward-center activation in research subjects
- Hormonal pathways related to feeding regulation
- Combination-therapy metabolic models
- Hormone-based energy-balance frameworks
These uses apply strictly to research environments and do not constitute guidance for human or veterinary use.
Why Choose Licensed Peptides for Cagrilintide Research Material?
Licensed Peptides provides research-grade Cagrilintide to U.S.-based laboratories operating under appropriate regulatory frameworks. Every vial is handled with care to protect peptide stability throughout the fulfillment process.
- High-quality research peptides
- Competitive pricing for scientific institutions
- Secure online ordering supporting major cards
- Prompt shipping within the United States
- Professional, protective packaging for sensitive research materials
All materials are clearly labeled FOR RESEARCH PURPOSES ONLY — NOT FOR HUMAN OR ANIMAL USE.
Frequently Asked Questions (Research-Only FAQ)
1. What is Cagrilintide?
Cagrilintide is an investigational amylin-receptor agonist studied for its potential roles in satiety signaling, metabolic regulation, and feeding-behavior research. It is used exclusively for laboratory research and is not intended for human or veterinary application.
2. How does Cagrilintide work in research models?
Studies show that Cagrilintide activates amylin pathways that regulate satiety signals. In research subjects, this results in measurable changes in feeding patterns, caloric intake, and appetite-related behaviors.
3. Is Cagrilintide the same as GLP-1 agents?
No. Cagrilintide targets the amylin receptor, whereas GLP-1 agonists target glucagon-like peptide-1 pathways. Their complementary mechanisms make them useful when evaluating combination models in metabolic research.
4. Does Cagrilintide reduce appetite in research subjects?
In controlled trials, Cagrilintide has been shown to influence satiety cues and reduce voluntary food intake in research subjects, making it valuable for appetite-regulation studies.
5. What is the primary research findings associated with Cagrilintide?
Findings include changes in satiety signaling, alterations in feeding rhythms, reduced food-seeking behavior, and modulated glucose-response patterns in research subjects.
6. How long does it take for effects to present in research models?
Many studies report observable appetite-related changes within 1–2 weeks in research subjects, though full pathway modulation appears over extended trial periods.
7. Can Cagrilintide be studied alongside GLP-1 agonists?
Yes. Research has demonstrated significant interest in combining Cagrilintide with GLP-1 agents to explore synergistic effects on metabolic and satiety pathways.
8. Does Cagrilintide affect blood-sugar patterns in research subjects?
Some studies indicate that Cagrilintide can influence post-meal glycemic markers and stabilize feeding-driven glucose oscillations in research models.
9. Is there evidence supporting its use in emotional-eating or reward-system research?
Cagrilintide appears to impact feeding reward-systems, making it useful for exploring binge-pattern behaviors or compulsive-eating models in laboratory research.
10. How long do the observed research effects last?
Due to its long receptor-activation profile, Cagrilintide exhibits extended effects in research subjects, enabling researchers to study longer cycles of metabolic signaling.
11. Are there side effects noted in research subjects?
As with most investigational hormones, some research models report effects such as nausea-like responses or altered feeding desire, which typically decrease as studies progress.
12. Is Cagrilintide appropriate for long-term research protocols?
Its extended-duration design makes it suitable for exploring long-term metabolic pathways, appetite regulation, and energy-balance studies in research subjects.
13. What does it mean that Cagrilintide is an LPS-free peptide?
An LPS-free peptide indicates that Cagrilintide has been tested to confirm the absence of lipopolysaccharides, which are bacterial endotoxins that can interfere with experimental outcomes. This is especially important for cellular, receptor, and signaling pathway research.
14. Why is endotoxin-free status important for research peptides?
Endotoxin contamination can activate unintended immune or stress responses in experimental systems. An endotoxin-free peptide helps ensure that observed effects are attributable to Cagrilintide itself rather than external contaminants.
15. Are Cagrilintide research peptides endotoxin tested?
Yes. Cagrilintide provided for research purposes is endotoxin tested, supporting consistency and reliability in sensitive laboratory applications, including in vitro and biochemical studies.
Cagrilintide: Research
What is Cagrilintide?
Obesity and type 2 diabetes are chronic, relapsing conditions that impose a major global health burden. Despite the success of glucagon-like peptide-1 receptor agonists (GLP-1RAs), many patients fail to achieve or sustain sufficient weight reduction with current therapies. Amylin, a peptide hormone co-secreted with insulin, has long been recognized as a target for weight and glycemic control due to its role in regulating satiety, gastric emptying, and postprandial glucagon secretion. However, the native hormone is unstable and prone to aggregation, limiting its therapeutic use.
Cagrilintide (NNC0174-0833) is a long-acting, acylated amylin analogue developed by Novo Nordisk. By combining the physiological actions of amylin with structural modifications that enhance stability and extend half-life, cagrilintide represents a new therapeutic approach for chronic weight management and type 2 diabetes.
Mechanism of Action
Cagrilintide is a 37–amino acid peptide structurally related to human amylin, modified with a C16 fatty diacid side chain linked via a γ-glutamic acid spacer at Lys²⁸. This lipidation promotes albumin binding, extending its plasma half-life to approximately one week, as characterised in published pharmacokinetic studies.
At the receptor level, cagrilintide activates amylin receptors, which are heterodimers consisting of the calcitonin receptor (CTR) combined with receptor activity-modifying proteins (RAMPs). Preclinical work has shown that cagrilintide’s weight-lowering effects are mediated primarily via AMY1 and AMY3 receptor subtypes, which are highly expressed in appetite-regulating regions of the brain. This results in reduced food intake, delayed gastric emptying, and improved satiety. Importantly, its mechanism is complementary to GLP-1 receptor agonists, making it an attractive candidate for combination therapy.
Scientific References
Published literature on cagrilintide is included here for educational and research-context purposes only. References to clinical trials, body-weight outcomes, glucose-related measures, or other human endpoints are not claims about this product and do not indicate that it is intended for human or animal use.
Summary
Cagrilintide is a research-grade amylin analogue used to support laboratory investigation of receptor biology and metabolic signaling pathways. Any discussion of experimental outcomes is limited to research context only. This product is not offered as a therapeutic, weight-management, or clinical product.
Cagrilintide : Reference Attribution
Scientific authors and literature references are provided solely to identify published research sources. They do not constitute endorsement, promotion, or any suggestion that this product is approved, safe, or intended for human or animal use.
Referenced Citations
Kruse T, Christoffersen BØ, Mortensen K, et al. Design and pharmacological characterization of cagrilintide (NNC0174-0833)… Journal of Medicinal Chemistry, 2021; 64(12):8942–8954. [View on Journal of Med Chem]
T.A Lutz, “Creating the Amylin Story”
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The products available on this website are intended solely for in-vitro research purposes (Latin: “in glass”), meaning they are used in experiments conducted outside a living organism. These products are not medicines or drugs, have not been evaluated or approved by the U.S. Food and Drug Administration (FDA), and are not intended to diagnose, treat, cure, or prevent any disease or medical condition. Any administration to humans or animals, whether by ingestion, injection, or other means, is strictly prohibited by law.
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Our peptides are commonly used in research involving:
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Every peptide we produce follows a strict, pharma-grade workflow designed to ensure purity, stability, and consistency from synthesis to delivery.
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Storage Instructions:
All of our products are manufactured using the Lyophilization (Freeze Drying) process, which ensures that our products remain 100% stable for shipping for up to 3-4 months.
Once the peptides are reconstituted (mixed with bacteriostatic water), they must be stored in the fridge to maintain stability. After reconstitution, the peptides will remain stable for up to 30 days.
Lyophilization is a unique dehydration process, also known as cryodesiccation, where the peptides are frozen and then subjected to low pressure. This causes the water in the peptide vial to sublimate directly from solid to gas, leaving behind a stable, crystalline white structure known as lyophilized peptide. The puffy white powder can be stored at room temperature until you’re ready to reconstitute it with bacteriostatic water.
Once peptides have been received, it is imperative that they are kept cold and away from light. If the peptides will be used immediately, or in the next several days, weeks or months, short-term refrigeration under 4C (39F) is generally acceptable. Lyophilized peptides are usually stable at room temperatures for several weeks or more, so if they will be utilized within weeks or months such storage is typically adequate.
However, for longer term storage (several months to years) it is more preferable to store peptides in a freezer at -80C (-112F). When storing peptides for months or even years, freezing is optimal in order to preserve the peptide’s stability.
For further information on proper storage techniques, click the link below:
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