BPC – 157 5mg

BPC – 157 Overview:

BPC-157 stands for Body Protection Compound-157, a synthetic pentadecapeptide—meaning it’s a chain of 15 amino acids. Discovered in the early 1990s, it was isolated from human gastric (stomach) juice and shows remarkable stability even in the harsh gastric environment

Preclinical Findings (Animal and Lab Studies)

Tissue Healing & Regeneration

BPC-157 has shown promising effects in animal models, accelerating healing in tissues such as skin, mucosa, muscle, tendon, ligament, bone, and even the cornea.

Mechanisms of Action

Though not fully elucidated, evidence suggests:

• Upregulation of growth factors (e.g., growth hormone receptor expression in tendon fibroblasts).
• Promotion of blood vessel formation (angiogenesis) and modulation of nitric oxide (NO) pathways

Safety in Animals

Preclinical studies across mice, rats, rabbits, and dogs consistently report no significant toxicity, suggesting a favorable safety profile in these models

BPC – 157: Structure

Source: pubchem

Sequence: GEPPPGKPADDAGLV
Molecular Formula: C₆₂H₉₈N₁₆O₂₂
Molecular Weight: ~1419.54 Da
PubChem CID: 9941957

BPC – 157: Research

Wound Healing & Tissue Regeneration

BPC-157 consistently accelerates repair across numerous injury models—skin ulcers, burns, muscle crushes, tendon and ligament tears, and even bone defects. These studies span rodents and rabbits.

Much work has been expended to demonstrate the potent effect of BPC 157 on the healing process in various experimental models in vivo (i.e., alkali-burn wounds, alloxan-induced gastric lesions) [78,79]. Indeed, this activity of the peptide was the first to be demonstrated, and it remained one of the most adequately described. Therefore, in order not to repeat the information given in several review papers, we refer the reader to some of those papers [80,81]. Nevertheless, a brief summary of healing properties induced by the compound is presented in Table 1.

Neuropsychiatric Disorders

Among mental disorders, depression, anxiety, and schizophrenia are the best known and most frequent. All those pathological conditions result from disturbances in the levels of various brain neurotransmitters such as serotonin (5-hydroxytryptamine (5-HT)) and dopamine. In major depressive disorder (MDD) and other depression-like conditions, it is still hypothesized that serotonin concentration, which is abnormally reduced, is the main factor [93]. However, as Moncrieff and colleagues point out in an attractive systemic review, there is no convincing evidence that depression could be associated with or caused by lower serotonin concentrations or activity [94]. With anxiety or schizophrenia, dopamine levels are elevated [95,96]. However, other neurotransmitters and receptor systems are also involved (e.g., γ-aminobutyric acid (GABA) and serotonin) [97,98]. Nevertheless, most first-line drugs for the treatment of those disorders target the serotonin and/or dopamine systems either directly (e.g., in depression) or indirectly via modulation of GABA-A receptors.

In 2004, it was reported that subcutaneous (s.c.) administration of the BPC 157 peptide to rats (10 μg/kg/day for 7 days) resulted in brain region-specific increases in serotonin synthesis [99], as determined by the precise alpha-[14C]methyl-L-tryptophan (alpha-MTrp) autoradiographic method. At the same time, the study was preceded by another one conducted by Sikiric et al. [100], who in 2000 showed that BPC 157 can serve as a potent antidepressant as measured by the Porsolt test (where peptide counteracts freezing). In addition, it was found that BPC 157 effectively reduced some of the symptoms occurring in the serotonin syndrome [26], thus exhibiting a rather specific counteraction of an excessive stimulation of 5-HT receptor subtypes (5-HT2A rather than 5-HT1A). This was demonstrated by the fact that administration of the peptide counteracted 5-HT receptor-dependent symptoms induced by pargyline + L-tryptophan, i.e., hyperthermia and wet dog shake related to 5-HT2A agonism, but not 5-HT1A-related forepaw treading, hind limb abduction, or hypothermia.

Other studies also clearly confirm its interactions with the dopaminergic system. In this context, BPC 157 was found to antagonize the anxiety behavior triggered by amphetamine, whose activity and effects were due to elevated extracellular dopamine levels [55,101]. Similarly, it alleviates withdrawal symptoms in animals chronically fed with diazepam [102], as upon withdrawal, the inhibitory influence of neurons was thought to be suppressed. This, in an effort to “compensate” for previous suppression of the release of DA, taking place during benzodiazepine administration, resulted in a sudden increase in DA concentrations [103].

BPC – 157 : Scientific Journal & Authors

Predrag Sikirić, Professor at the University of Zagreb, has been a leading contributor to research on the stable gastric pentadecapeptide BPC-157. He is the primary author of “Novel Cytoprotective Mediator, Stable Gastric Pentadecapeptide BPC-157: Vascular Recruitment and Gastrointestinal Tract Healing” and a co-author of “Stable Gastric Pentadecapeptide BPC-157 in Honeybee (Apis mellifera) Therapy to Control Nosema ceranae Invasions in Apiary Conditions.”

Referenced Citations

Stable Gastric Pentadecapeptide BPC 157 as a Therapy and Safety Key: A Special Beneficial Pleiotropic Effect Controlling and Modulating Angiogenesis and the NO-System

Predrag Sikiric 1, Sven Seiwerth 2, Anita Skrtic 2, Mario Staresinic 3, Sanja Strbe 1, Antonia Vuksic 1, Suncana Sikiric 2, Dinko Bekic 1, Dragan Soldo 1, Boris Grizelj 1, Luka Novosel 1 4, Lidija Beketic Oreskovic 1, Ivana Oreskovic 1, Mirjana Stupnisek 1, Alenka Boban Blagaic 1, Ivan Dobric 1 3

Józwiak M, Bauer M, Kamysz W, Kleczkowska P. Multifunctionality and Possible Medical Application of the BPC 157 Peptide-Literature and Patent Review. Pharmaceuticals (Basel). 2025 Jan 30;18(2):185. doi: 10.3390/ph18020185. PMID: 40005999; PMCID: PMC11859134.

 

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The products available on this website are intended solely for in-vitro research purposes (Latin: “in glass”), meaning they are used in experiments conducted outside a living organism. These products are not medicines or drugs, have not been evaluated or approved by the U.S. Food and Drug Administration (FDA), and are not intended to diagnose, treat, cure, or prevent any disease or medical condition. Any administration to humans or animals, whether by ingestion, injection, or other means, is strictly prohibited by law.

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Storage Instructions:

All of our products are manufactured using the Lyophilization (Freeze Drying) process, which ensures that our products remain 100% stable for shipping for up to 3-4 months.

Once the peptides are reconstituted (mixed with bacteriostatic water), they must be stored in the fridge to maintain stability. After reconstitution, the peptides will remain stable for up to 30 days.

Lyophilization is a unique dehydration process, also known as cryodesiccation, where the peptides are frozen and then subjected to low pressure. This causes the water in the peptide vial to sublimate directly from solid to gas, leaving behind a stable, crystalline white structure known as lyophilized peptide. The puffy white powder can be stored at room temperature until you’re ready to reconstitute it with bacteriostatic water.

Once peptides have been received, it is imperative that they are kept cold and away from light. If the peptides will be used immediately, or in the next several days, weeks or months, short-term refrigeration under 4C (39F) is generally acceptable. Lyophilized peptides are usually stable at room temperatures for several weeks or more, so if they will be utilized within weeks or months such storage is typically adequate.

However, for longer term storage (several months to years) it is more preferable to store peptides in a freezer at -80C (-112F). When storing peptides for months or even years, freezing is optimal in order to preserve the peptide’s stability.

For further information on proper storage techniques, click the link below:

Peptide Storage