KPV · 10mg

Overview

KPV is a laboratory research material used to examine peptide behavior, receptormediated signaling, and inflammatory pathway responses in controlled experimental models. References to biological effects are provided for scientific context only and must not be interpreted as claims of therapeutic, diagnostic, or clinical benefit. This product is not offered for human or veterinary use.

KPV: Structure

Amino Acid Sequence: Lys–Pro–Val
Molecular Formula: C₁₆H₃₀N₄O₄
Molecular Weight: 342.43 g/mol
PubChem CID: 125672
CAS Number: 67727-97-3
Synonyms: MSH (11-13), ACTH (11-13), α-MSH (11-13)

Source: PubChem

Why Researchers Choose KPV

KPV is used in laboratory settings to study receptor-mediated signaling, cytokineresponse behavior, epithelial biology, and assay development. Any references to inflammatory, gastrointestinal, dermal, or barrier-related pathways are limited to research context only and do not imply approved human or animal use.

Gut-Barrier Research Context

In laboratory models, KPV may be used to investigate epithelial integrity, mucosal signaling, and pathway-response behavior. Any mention of intestinal, colitis-related, or barrier-related systems is provided only for research context and must not be interpreted as a human-use claim.

Dermal Research Context

KPV may be used in laboratory studies involving epithelial signaling and dermal model systems. References to skin or wound-related research are limited to experimental context only and do not imply therapeutic, cosmetic, or clinical benefit.

High Stability, Purity, and Reliability

Research-grade KPV 10mg is typically produced under strict conditions to ensure:

• High purity suitable for regulated laboratory experimentation
• Strong stability under recommended storage techniques
• Consistent fill accuracy
• Protection from moisture, temperature fluctuations, and degradative exposure

These manufacturing priorities help ensure the peptide behaves predictably in scientific studies.

What Makes KPV 10mg Unique?

KPV stands out among research peptides because it is:

• Structurally simple yet highly specific, allowing researchers to focus on defined pathways
• Well-tolerated in laboratory models, with low interference across unrelated biological systems
• Free from pigment-altering effects, unlike α-MSH and its derivatives
• Versatile across inflammatory, epithelial, immune, metabolic, and dermatological research areas
• Valuable in experiments requiring non-hormonal signaling mechanisms

Investigators appreciate that KPV frequently demonstrates biological relevance in model systems without triggering unwanted peripheral effects.

Why Choose Licensed Peptides for KPV 10mg?

Licensed Peptides is committed to supplying research-grade KPV 10mg with consistency, transparency, and rigorous quality standards. Operating within the United States, our processes emphasize stable formulation, precise purity, and professional handling from manufacturing through delivery. Each batch undergoes strict quality controls to ensure suitability for laboratory research, not for human or animal consumption.

FAQs About KPV 10mg

(All information is strictly for research applications. Not intended for human or animal use.)

1. What is KPV?

KPV is a synthetic tripeptide used in laboratory research to study peptide behavior and signaling pathways.

2. What is KPV used for in research?

It may be used in receptor studies, inflammatory signaling analysis, epithelial biology, and assay development.

3. How should KPV 10mg be stored?

Most suppliers recommend:

• Storing at -20°C until use
• Protecting from moisture and light
• Reconstituting only immediately prior to experimentation

Researchers must always follow the specific instructions provided with their batch.

4. What form does KPV 10mg usually arrive in?

Research-grade KPV typically arrives as a lyophilized powder designed for dilution or reconstitution within laboratory protocols. Handling guidelines vary by supplier and application.

5. Is KPV stable after reconstitution?

Stability post-reconstitution depends on storage conditions, temperature, and duration. Many researchers prepare only the quantity needed for immediate testing to preserve integrity.

6. Is it intended for human or animal use?

No. It is supplied strictly for research use only.

7. Does this page describe therapeutic or disease-related effects?

No. Any scientific discussion on this page is limited to research context only and should not be interpreted as a claim of therapeutic, diagnostic, or clinical benefit.

8. Why is endotoxin-free testing important for research peptides like KPV?

Endotoxins can significantly alter inflammatory and immune signaling in laboratory models. An endotoxin-free peptide that is research peptides endotoxin tested helps ensure that observed effects are attributable to the peptide itself rather than external contaminants.

9. Is KPV 10 mg suitable for sensitive cell or tissue studies?

Yes, when supplied as a high-purity, LPS-free peptide, KPV 10 mg is commonly used in controlled laboratory studies where low endotoxin levels are critical for experimental accuracy.

10. How does endotoxin testing support research reliability?

Endotoxin testing provides quality assurance by confirming that the peptide meets strict laboratory standards. This helps researchers maintain consistency, reproducibility, and integrity across experimental protocols involving KPV.

Referenced Citations

Transdermal Iontophoretic Delivery of Lysine-Proline-Valine (KPV) Peptide Across Microporated Human Skin

Pawar, Kasturi et al.
Journal of Pharmaceutical Sciences, Volume 106, Issue 7, 1814 – 1820

Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease
Klaus Kannengiesser, MD , Christian Maaser, MD , Jan Heidemann, MD , Andreas Luegering, MD , Matthias Ross, MD , Thomas Brzoska, PhD , Markus Bohm, MD , Thomas A. Luger, MD , Wolfram Domschke, MD , Torsten Kucharzik, MD

Xiao B, Xu Z, Viennois E, Zhang Y, Zhang Z, Zhang M, Han MK, Kang Y, Merlin D. Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles Efficiently Alleviates Ulcerative Colitis. Mol Ther. 2017 Jul 5;25(7):1628-1640. doi: 10.1016/j.ymthe.2016.11.020. Epub 2017 Jan 28. PMID: 28143741; PMCID: PMC5498804.

ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.

The products available on this website are intended solely for in-vitro research purposes (Latin: “in glass”), meaning they are used in experiments conducted outside a living organism. These products are not medicines or drugs, have not been evaluated or approved by the U.S. Food and Drug Administration (FDA), and are not intended to diagnose, treat, cure, or prevent any disease or medical condition. Any administration to humans or animals, whether by ingestion, injection, or other means, is strictly prohibited by law.

It’s important to store peptides correctly in order to preserve their structure and stability. Here at Licensed Peptides, we supply KPV in a lyophilized (freeze-dried) form to keep it stable during shipping and while storing.

What Is Lyophilization?

Lyophilization, sometimes called freeze-drying, is a process that removes moisture from peptides by freezing them and exposing them to low pressure. During this process, water sublimates directly from solid to vapor, resulting in a stable, crystalline white powder.

Note that lyophilized KPV will tolerate storage conditions well, and it can stay stable for longer.

Storage of KPV Before Reconstitution

Store unopened lyophilized KPV at room temperature for short periods without compromising peptide quality. Ensure you store the KPV vials in a cool, dry environment and keep them away from excessive heat, humidity, and direct light.

Short-Term Storage

Refrigerate KPV vials below 4°C (39°F) for near-term experimental use. At this temperature, lyophilized KPV may retain its integrity for several weeks.

Long-Term Storage

Place unopened vials in a freezer. Researchers commonly use temperatures of -20°C (-4°F), while -80°C (-112°F) provides an additional margin of protection for long-term preservation and archival storage.

Storage of KPV After Reconstitution

Once you reconstitute your KPV peptide with bacteriostatic water, refrigeration becomes essential.

• Store reconstituted solutions below 4°C (39°F)
• Do not freeze-thaw the peptide repeatedly (temperature fluctuations may affect peptide integrity)

Important: In the right conditions, reconstituted KPV peptide solutions may remain suitable for use for up to 30 days.

KPV Peptide Research Overview

We supply KPV exclusively for research. Our 6-point verification process guarantees that you’ll receive a certified peptide that you can use in analytical testing, in vitro research, and experimental models.

Our Research-Grade Standards

We understand the importance of purity and sterility in research compounds; that’s why we manufacture our peptides under strict quality standards in GMP-certified facilities. We also work with independent accredited laboratories who verify each batch, using our 6-point verification process:

• High-Performance Liquid Chromatography (HPLC) analysis to check for 99%+ purity
• Mass spectrometry to confirm the molecular identity of each peptide and whether its sequence is accurate
• Screening for heavy metals, endotoxins, and lipopolysaccharides (LPS)
• Verification of sterility through an ISO/IEC 17025:2017-accredited laboratory
• Our team also confirms that the content (weight and concentration) are accurate
• We physically inspect every vial for lyophilization quality, label accuracy, and overall appearance

Application of KPV: Why Researchers Study this Peptide

Because KPV is the active C-terminal fragment of α-MSH,3 it’s now the subject of many studies. Researchers are studying its involvement in different signaling pathways in immune communication and epithelial biology. Studies reveal that KPV interacts with different cellular processes,1 which is why it’s an interesting compound for mechanistic research.

Currently, researchers are investigating KPV in:

• Research on inflammatory signaling
• Cytokine communication pathways
• NF-κB signaling studies
• Intestinal epithelial models
• Mucosal barrier investigations
• Pulmonary inflammatory models
• Dermatological research models
• Cellular communication studies
• Structure-activity relationship investigations
• Peptide transport research

Cytokine Signaling Research

Researchers examine how KPV interacts with inflammatory responses mediated by cytokines. This is because KPV may influence signaling pathways that are linked to pro-inflammatory mediators.3 They continue evaluating these interactions across different tissue models to determine whether KPV exhibits consistent activity under varying experimental conditions.

NF-κB Pathway Investigations

One of the most extensively studied mechanisms of KPV involves the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway. Preclinical research indicates that KPV may influence NF-κB activation and the downstream expression of inflammatory signaling molecules.2 Because NF-κB regulates numerous genes involved in immune communication, this pathway remains an active area of peptide research.

MAPK Signaling Studies

Researchers have also explored the interaction of KPV with mitogen-activated protein kinase (MAPK) pathways. These pathways regulate cellular responses to external stimuli. Scientists continue to study these mechanisms to better understand the regulation of cellular communication networks by peptides.

Peptide Transport Research

Unlike many larger peptides that exhibit limited oral stability in experimental settings, researchers continue to study the transport of KPV through the Peptide Transporter 1 (PepT1) system expressed within intestinal epithelial cells.1 Scientists are interested in this transport mechanism because it may help explain how small tripeptides behave differently from larger peptide molecules during laboratory investigations.

KPV Compared With Related Melanocortin Peptides

Important Notice

Licensed Peptides supplies KPV Peptide exclusively for research. It’s not approved for human or veterinary use. Any discussion concerning the biological activity of KPV refers to preclinical and in vitro studies only.

References

1. Dalmasso G, Charrier-Hisamuddin L, Nguyen HT, Yan Y, Sitaraman SV, Merlin D. PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation. Gastroenterology. 2008;134(1):166-178. doi:10.1053/j.gastro.2007.10.026

2. Land SC. Inhibition of cellular and systemic inflammation cues in human bronchial epithelial cells by melanocortin-related peptides: mechanism of KPV action and a role for MC3R agonists. Int J Physiol Pathophysiol Pharmacol. 2012;4(2):59-73.

3. Luger TA, Brzoska T. Alpha-MSH related peptides: a new class of anti-inflammatory and immunomodulating drugs. Ann Rheum Dis. 2007;66(suppl 3):iii52-iii55. doi:10.1136/ard.2007.079780

Why Buy KPV Peptide From Licensed Peptides

At Licensed Peptides™, quality is a controlled, repeatable process. Every batch of KPV follows a strict, pharma-grade workflow, ensuring the peptides you purchase are stable and pure, from synthesis to delivery.

What Sets Us Apart:

ISO-Certified Cleanroom Manufacturing

We synthesize all our KPV peptides in sterile, controlled environments to reduce the risk of contamination. This ensures consistency across every single batch.

>99% Verified Purity (HPLC Tested)

In order to verify purity with precision, we use advanced High-Performance Liquid Chromatography (HPLC) analysis. This means your peptides are free from unwanted chemicals and impurities.

Triple-Verified Identity, Endotoxin-Free, LPS-Free KPV Peptides

We use mass spectrometry to confirm molecular identity and test each batch of KPV for endotoxins and lipopolysaccharides (LPS) using Limulus Amebocyte Lysate (LAL). Each batch also undergoes HPLC purity analysis.

Endotoxin-Controlled Production

We supply KPV peptides with verified endotoxin reports. Low endotoxin levels are important in sensitive receptor-signaling studies where inflammatory contaminants may influence the outcome of the experiment.

Pharma-Grade Raw Materials

Our manufacturing process begins with rigorously tested amino acids and validated reagents. This procedure protects the molecular integrity of KPV throughout peptide synthesis.

Lyophilized for Stability

Freeze-dried KPV peptide is more stable, which means it’s less likely to degrade during experimentation, and it keeps its structural integrity intact. This ensures it’s reliable for lab work.

Nitrogen-Sealed Vials

We seal each KPV peptide vial in nitrogen to minimize exposure to oxygen and moisture. This preserves integrity while you’re transporting and storing the peptide.

Made for Serious Research

From peptide synthesis to final fulfillment, we meet the expectations of researchers who need dependable sourcing to ensure they create reproducible studies.

Shipping

We understand that timing and product integrity are critical for research.

Same-Day Shipping (USA)

We ship all in-stock orders of KPV placed before our daily cutoff the same day within the United States.

Fast Domestic Delivery (1–3 Days)

We use expedited carriers to ensure your KPV peptide arrives quickly and reliably nationwide.

Cold Chain Protection

We store our KPV peptides in industrial-grade freezers prior to shipment to support stability and purity.

Secure & Protective Packaging

We carefully pack each order to reduce exposure to temperature fluctuations, moisture, and physical damage during transit.

Real-Time Tracking

We provide tracking information immediately after shipment so researchers can monitor delivery progress.

Consistency You Can Rely On

No international delays. No customs uncertainty. Just dependable fulfillment from a U.S.-based operation.

Additional information