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CJC-1295 NO DAC
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99%+ HPLC Purity — Independently verified by accredited US laboratory -
Endotoxin-Screened — LAL tested, LPS-free, endotoxin report available
-
GMP-Certified Manufacturing — USA facility, ISO 9001:2015
-
Lyophilized for Stability — Shipped cold-packed, intact for reconstitution
Molecular Weight
Third Party Tested
APPLICATION
For Research Use only
Form
Lyophilized Powder
Storage
-20°C Long Term
Purity (HPLC)
99%+ Third Party Verified
Manufacture
USA / GMP
4.9 847 verified reviews
CJC-1295 NO DAC
Total Price
$173.93
Discounted Price
$144.36
Vials
3 vials
You Save
$29.57
17% OFF
Select Strength (mg)
99% HPLC Purity
Select Vials
Bulk pricing applied
📈 Upgrade to 10 vials and save an extra vs. buying 5 — nearly 3 free vials.
Select Purchase Option:
-
99%+ HPLC Purity —
Independently verified by accredited US laboratory
-
Endotoxin-Screened —
LAL tested, LPS-free, endotoxin report available
-
GMP-Certified Manufacturing —
USA facility, ISO 9001:2015
-
Lyophilized for Stability —
Shipped cold-packed, intact for reconstitution
Molecular Weight
Third Party Tested
APPLICATION
For Research Use only
Form
Lyophilized Powder
Storage
-20°C Long Term
Purity (HPLC)
99%+ Third Party Verified
Manufacture
USA / GMP
CJC-1295 NO DAC is a research peptide used in laboratory studies of GHRH receptor activity, peptide stability, and controlled signaling pathways in experimental models. This product is supplied strictly for research use only. It is not approved or intended for human or animal use, and any discussion of biological activity refers only to preclinical or in vitro research.
In contrast to DAC (Drug Affinity Complex) versions, which remain active for extended periods because of the affinity complex that binds to serum proteins, the NO-DAC form is intentionally brief in duration. This characteristic allows for more precise timing, closer alignment with natural GH pulsatility, and a cleaner signaling window that is often advantageous in controlled studies. Research protocols examining circadian influences, acute cellular responses, metabolic pathways, and tissue-specific GH interactions frequently utilize this short-acting design for data accuracy.
For laboratory applications, CJC-1295 NO DAC is typically supplied as a high purity, LPS-free peptide, manufactured under controlled conditions to support experimental consistency. Each batch is produced as an endotoxin-free peptide, with research peptides endotoxin tested to help ensure suitability for sensitive in-vitro and ex-vivo research environments. These quality attributes are particularly important in studies where immune activation, inflammatory signaling, or cellular stress responses may influence experimental outcomes.
This compound is intended strictly for research purposes only. Not for human or animal use.
CJC-1295 NO DAC at a glance
| Molecular formula | C₁₅₂H₂₅₂N₄₄O₄₂ |
|---|---|
| Molecular weight | ~3368.7 g/mol |
| Length | 29 amino acids |
| Application | Research use only |
What is CJC-1295 NO DAC?
CJC-1295 NO DAC is a laboratory research material used to study receptor signaling, peptide kinetics, and time-dependent endocrine pathway behavior in controlled experimental systems. References to biological effects are provided for scientific context only and must not be interpreted as claims of therapeutic, diagnostic, or clinical benefit. This product is not offered for human or veterinary use.
CJC-1295 (No DAC) is a synthetic 29-amino-acid analogue of the N-terminal fragment of growth-hormone-releasing hormone, GRF(1-29), carrying substitutions that reduce enzymatic cleavage at the dipeptidyl-peptidase site. It is supplied lyophilised and is soluble in aqueous buffer after reconstitution.3
Why is CJC-1295 NO DAC studied?
CJC-1295 (No DAC) is the modified GRF(1-29) sequence without the drug-affinity-complex linker. It is studied as the short-acting reference point for that chemistry: the same receptor-binding fragment, but without the albumin-conjugation chemistry that extends circulating half-life in the parent analogue.3
How is CJC-1295 NO DAC studied in the lab?
In laboratory models, this peptide is used to investigate receptor-mediated signaling events and downstream experimental readouts. Any references to endocrine pathways, IGF-1, or timing-dependent signaling are included only to describe research context and must not be interpreted as claims of human or animal use.
What has preclinical research reported?
Research Context
This compound is used in laboratory settings to examine short-acting receptor-mediated signaling and downstream pathway responses. Any mention of pulse timing, signaling windows, or experimental precision relates only to research methodology and does not imply human-use benefits.
Key Areas of Interest
- Receptor-binding research
- Short-acting peptide kinetics
- Signal-duration studies
- Experimental pathway analysis
- Circadian timing models
- Protein signaling research
- Laboratory assay development
All uses are limited to research settings only. This product is not intended for diagnosis, treatment, prevention, or consumption.
CJC-1295 No DAC & Intestine
Researchers developed several stable analogues of growth hormone-releasing factor (GRF) and characterised their receptor activity. One potent analogue, GRF-6, caused severe diarrhea in monkeys during prolonged infusion but had no adverse effects in rats. Since GRF shares structural similarities with VIP/PACAP peptides, which are known to cause diarrhea when overproduced, the study examined whether GRF analogues interact with VIP/PACAP receptors.
Key Results:
- Native hGRF(1-29) had weak binding to rat and human VPAC1/VPAC2 receptors, while VIP bound strongly.
- GRF-6 showed weak binding to rat receptors but higher affinity for the human VPAC1 receptor (not VPAC2).
- In guinea pig pancreatic cells, all GRF analogues acted as full agonists, triggering enzyme release.
Conclusion
Unlike natural hGRF, GRF-6 selectively interacts with the human VPAC1 receptor, which likely explains the diarrhea observed in monkeys. The study highlights species differences in receptor response between the models tested.
GRF receptor activation (rat anterior pituitary)
hGRF(1-29) bioconjugates were shown to activate the growth-hormone-releasing-factor receptor on the rat anterior pituitary, establishing the receptor pharmacology of this sequence family.3
Forms studied and handling
Supplied as a lyophilised powder in a sealed vial. Published handling practice for research peptides of this class is cold, dry, light-protected storage of the lyophilised solid, with reconstituted material kept refrigerated and used within the stability window established by the laboratory. For laboratory research use only.
References
- Ito T, Igarashi H, Pradhan TK, Hou W, Mantey SA, Taylor JE, Murphy WA, Coy DH, Jensen RT. GI side-effects of a possible therapeutic GRF analogue in monkeys are likely due to VIP receptor agonist activity. Peptides. 2001 Jul;22(7):1139-51. doi: 10.1016/s0196-9781(01)00436-3. PMID: 11445245. PMID 11445245
- Valcavi R, Jordan V, Dieguez C, John R, Manicardi E, Portioli I, Rodriguez-Arnao MD, Gomez-Pan A, Hall R, Scanlon MF. Growth hormone responses to GRF 1-29 in patients with primary hypothyroidism before and during replacement therapy with thyroxine. Clin Endocrinol (Oxf). 1986 Jun;24(6):693-8. doi: 10.1111/j.1365-2265.1986.tb01666.x. PMID: 3098458. PMID 3098458
- Jette L, Leger R, Thibaudeau K, et al. Human growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analog. Endocrinology. 2005;146(7):3052-3058. doi:10.1210/en.2004-1286
For laboratory research use only. Products on this website are intended solely for in-vitro research. They are not medicines, have not been evaluated by the FDA, and are not intended to diagnose, treat, cure, or prevent any disease. Any administration to humans or animals is strictly prohibited.
What are these peptides made for?
Our peptides are produced exclusively for laboratory and scientific research purposes.
Licensed Peptides™ products are developed using industry-standard synthesis and purification protocols, making them suitable for in vitro research, analytical testing, and experimental models.
Research-grade standards
- Synthesized via Solid Phase Peptide Synthesis (SPPS)
- Purified using advanced HPLC methods
- Verified through analytical quality control processes
- Screened for heavy metals and endotoxins
Consistency across batches
Strict process controls ensure reproducibility, allowing researchers to work with confidence across experiments.
Applications
Our peptides are commonly used in research involving:
- Cellular signaling pathways
- Tissue remodeling and repair mechanisms
- Extracellular matrix regulation
- Molecular biology and biochemical studies
All products are intended for research use only and are not for human or animal consumption, therapeutic use, or clinical application.
Why buy from Licensed Peptides
At Licensed Peptides™, quality isn’t a claim — it’s a controlled, repeatable process.
Every peptide we produce follows a strict, pharma-grade workflow designed to ensure purity, stability, and consistency from synthesis to delivery.
What sets us apart
ISO-certified cleanroom manufacturing
All peptides are synthesized in sterile, controlled environments to eliminate contamination risk and ensure batch consistency.
>99% verified purity (HPLC tested)
We use advanced High-Performance Liquid Chromatography (HPLC) to separate and verify peptide purity with precision.
Comprehensive safety testing
Each batch undergoes heavy metal and endotoxin screening to ensure it is free from hidden contaminants.
Pharma-grade raw materials
We start with rigorously tested amino acids and reagents, ensuring integrity at the molecular level.
Lyophilized for stability
Freeze-dried peptides maintain long-term stability, potency, and reliability for research applications.
Nitrogen-sealed vials
Every vial is protected from oxygen and moisture, preserving structural integrity during storage and transit.
Built for serious research
From synthesis to delivery, every step is engineered to meet the expectations of professionals who require accuracy, consistency, and reliability.
For laboratory research use only. Not for human or veterinary use.
How orders ship
We understand that timing and product integrity are critical for research.
| Ships to | United States (including minor outlying islands) |
|---|---|
| Processing days | Monday to Friday, excluding holidays |
| Daily cut-off | Paid orders placed before 4:00 PM PST are typically shipped the same business day |
| Free shipping | FedEx 2-Day Express on orders over $200 and for VIP members |
| Standard | USPS Ground Advantage, 3–7 business days (not guaranteed) — $8.95 |
| Expedited | FedEx 2-Day $11.95 · UPS 2-Day $19.95 · FedEx Next Day $44.99 |
| Signature | Required on delivery for orders of $1,000 or more |
How orders are handled
Cold chain protection
Products are stored in industrial-grade freezers prior to shipment to maintain stability and purity.
Secure & protective packaging
Each order is carefully packed to protect against temperature fluctuations, moisture exposure, and physical damage during transit.
Tracking
Once your order has shipped you will receive a tracking number by email, so you can monitor delivery progress.
Shipped from the United States
Orders are dispatched domestically from a U.S.-based operation, so there are no international customs steps.
Delivery times
Shipping times are estimates and begin after order processing. Delays may occur due to carrier issues, weather, or other unforeseen factors, and delivery dates are not guaranteed. Full terms are in our Shipping & Delivery Policy.
For laboratory research use only. Not for human or veterinary use.
Additional information
| pack | 1 pack, 3 pack, 5 pack, 10 pack |
|---|
Storage conditions at a glance
| Lyophilized, in transit | Stable for shipping for up to 3–4 months |
|---|---|
| Lyophilized, short term | Room temperature is usually adequate for several weeks; refrigeration under 4°C (39°F) is generally acceptable |
| Lyophilized, long term | Freezer at -80°C (-112°F) for several months to years |
| After reconstitution | Refrigerated; stable for up to 30 days |
| Light and moisture | Keep cold and away from light in the original sealed vial |
Why the powder is stable
All of our products are manufactured using the lyophilization (freeze drying) process, which keeps them stable for shipping for up to 3–4 months.
Lyophilization is a unique dehydration process, also known as cryodesiccation, where the peptides are frozen and then subjected to low pressure. This causes the water in the peptide vial to sublimate directly from solid to gas, leaving behind a stable, crystalline white structure known as lyophilized peptide. The puffy white powder can be stored at room temperature until it is reconstituted with bacteriostatic water.
Storing vials on arrival
Once peptides have been received, it is imperative that they are kept cold and away from light. If the peptides will be used in the next several days, weeks or months, short-term refrigeration under 4°C (39°F) is generally acceptable. Lyophilized peptides are usually stable at room temperatures for several weeks or more, so if they will be utilized within weeks or months such storage is typically adequate.
For longer term storage (several months to years) it is more preferable to store peptides in a freezer at -80°C (-112°F). When storing peptides for months or even years, freezing is optimal in order to preserve the peptide’s stability.
After reconstitution
Once the peptides are reconstituted with bacteriostatic water, they must be stored in the fridge to maintain stability. After reconstitution, the peptides will remain stable for up to 30 days.
For laboratory research use only. Not for human or veterinary use.
99%+ — Passes ≥99% 
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