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Epithalon
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99%+ HPLC Purity — Independently verified by accredited US laboratory -
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GMP-Certified Manufacturing — USA facility, ISO 9001:2015
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Lyophilized for Stability — Shipped cold-packed, intact for reconstitution
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APPLICATION
For Research Use only
Form
Lyophilized Powder
Storage
-20°C Long Term
Purity (HPLC)
99%+ Third Party Verified
Manufacture
USA / GMP
4.9 847 verified reviews
Epithalon
Total Price
$480.53
Discounted Price
$321.95
Vials
5 vials
You Save
$158.58
33% OFF
Select Strength (mg)
99% HPLC Purity
Select Vials
Bulk pricing applied
📈 Upgrade to 10 vials and save an extra vs. buying 5 — nearly 3 free vials.
Select Purchase Option:
-
99%+ HPLC Purity —
Independently verified by accredited US laboratory
-
Endotoxin-Screened —
LAL tested, LPS-free, endotoxin report available
-
GMP-Certified Manufacturing —
USA facility, ISO 9001:2015
-
Lyophilized for Stability —
Shipped cold-packed, intact for reconstitution
Molecular Weight
Third Party Tested
APPLICATION
For Research Use only
Form
Lyophilized Powder
Storage
-20°C Long Term
Purity (HPLC)
99%+ Third Party Verified
Manufacture
USA / GMP
Epithalon (also known as Epitalon) is a synthetic tetrapeptide used in laboratory research to study telomere biology, peptide signaling, and related cellular pathways in controlled experimental systems. This product is supplied strictly for research use only. It is not approved or intended for human or animal use, and any discussion of biological activity refers only to preclinical or in vitro research.
Epithalon has attracted significant interest within the fields of aging biology and molecular research due to its observed interactions with telomerase activity and telomere dynamics in controlled experimental models. Telomeres are repetitive nucleotide sequences located at the ends of chromosomes that function as protective structures, maintaining chromosomal stability during successive cellular divisions. Progressive telomere shortening has been consistently associated with cellular senescence and replicative limits in a wide range of in vitro and experimental studies.
Experimental investigations involving Epithalon have primarily focused on its molecular signaling properties, gene expression modulation, and chromosomal endpoint behavior under laboratory conditions. These findings are derived from controlled research environments and are intended solely to advance scientific understanding of cellular aging mechanisms and peptide–DNA interactions.
Epithalon supplied for research applications is typically manufactured to high purity standards and is characterized as an LPS-free peptide, endotoxin-free peptide, and research peptide endotoxin tested to ensure suitability for sensitive laboratory assays, cellular studies, and biochemical analysis. These quality attributes are critical for minimizing experimental interference and maintaining data integrity in research settings.
Importantly, Epithalon is not approved for medical, veterinary, or dietary use. All discussion surrounding this compound pertains strictly to laboratory, cellular, or experimental research settings. No claims are made regarding therapeutic outcomes, enhancement of human health, or clinical efficacy.
Epithalon at a glance
| Sequence | Ala-Glu-Asp-Gly |
|---|---|
| Molecular formula | C₁₄H₂₂N₄O₉ |
| Molecular weight | 390.349 g/mol |
| CAS number | 307297-39-8 |
| PubChem CID | 219042 |
| Form supplied | Lyophilized powder |
| Application | Research use only |
What is Epithalon?
Epithalon is a laboratory research material used to examine telomere biology, cellular senescence models, and peptide-mediated signaling pathways in controlled experimental systems. References to biological effects are provided for scientific context only and must not be interpreted as claims of therapeutic, diagnostic, or clinical benefit. This product is not offered for human or veterinary use.
Why is Epithalon studied?
Epithalon is a synthetic peptide used in controlled laboratory models to study gene expression, chromosome stability, and related molecular pathways. Any discussion of pineal-gland lineage, circadian biology, or aging-associated pathways is presented solely as research context and does not imply human-use benefits.
How is Epithalon studied in the lab?
A useful analogy often employed in educational settings compares a cell’s genome to a reference library. Telomeres act as protective bindings on each volume. With repeated copying, those bindings’ fray, risking loss of critical data. Epithalon, in this framework, is studied as a molecular signal that may influence how well those bindings are preserved during replication.
This analogy is conceptual only and is used to simplify complex genomic processes for research discussion.
What has preclinical research reported?
Pineal Gland Association and Circadian Research
The pineal gland plays a central role in circadian rhythm regulation through the secretion of melatonin. Because Epithalon is derived from peptides originally associated with pineal signaling, researchers have examined its influence on circadian-regulated gene expression and endocrine signaling patterns in experimental models.
Laboratory findings suggest that Epithalon may modulate expression patterns linked to circadian rhythm stability, particularly in aging cellular systems where rhythmic signaling tends to deteriorate. These effects are often studied through molecular markers rather than behavioral outcomes, reinforcing the strictly mechanistic nature of this research.
Oxidative Stress and Cellular Defense Pathways
Another area of interest involves Epithalon’s potential relationship with oxidative stress regulation. Oxidative stress arises from an imbalance between reactive oxygen species (ROS) and cellular antioxidant defenses, contributing to DNA damage, protein misfolding, and cellular aging.
Experimental investigations have reported changes in antioxidant enzyme activity and oxidative markers following Epithalon exposure in controlled environments. Rather than directly scavenging free radicals, Epithalon appears to influence regulatory pathways responsible for maintaining intracellular redox balance.
Again, these findings are relevant solely to biochemical and molecular research and are not indicative of protective effects in living organisms.
What Makes Epithalon Distinct in Research Contexts
- Telomere-Focused Investigation: Few research peptides are consistently examined for direct associations with telomere length and telomerase activity, positioning Epithalon as a unique tool in chromosomal aging studies.
- Pineal Peptide Lineage: Its derivation from pineal gland peptides links Epithalon to neuroendocrine and circadian rhythm research.
- Intracellular Signaling Modulation: Rather than acting as a direct antioxidant or hormone analogue, Epithalon is studied for its signaling and regulatory roles within cells.
- Longevity Model Relevance: Epithalon frequently appears in experimental designs focused on lifespan, replicative capacity, and age-associated molecular changes.
Intended Research Applications
Epithalon is commonly investigated within the following research domains:
- Telomere biology
- Cellular senescence modeling
- Molecular pathway analysis
- Gene expression studies
- Chromosome stability research
- Oxidative stress pathway research
- Circadian gene regulation research
- Endocrine signaling research
All uses are limited to laboratory research only. This product is not intended for diagnosis, treatment, prevention, or consumption.
Forms studied and handling
Epithalon is typically supplied in lyophilized (freeze-dried) form to preserve structural stability. Standard laboratory practice involves storage in cool, dry environments, often under refrigeration. Once reconstituted for experimental use, stability parameters depend on solvent choice, temperature, and duration, requiring strict adherence to research protocols.
References
- Korkushko OV, Khavinson VKh, Shatilo VB, Antonyuk-Shcheglova IA. Geroprotective effect of epithalamine (pineal gland peptide preparation) in elderly subjects with accelerated aging. Bull Exp Biol Med. 2006 Sep;142(3):356-9. English, Russian. doi: 10.1007/s10517-006-0365-z. PMID: 17426848. PMID 17426848
- Anisimov VN, Mylnikov SV, Khavinson VK. Pineal peptide preparation epithalamin increases the lifespan of fruit flies, mice and rats. Mech Ageing Dev. 1998 Jun 15;103(2):123-32. doi: 10.1016/s0047-6374(98)00034-7. PMID: 9701766. PMID 9701766
For laboratory research use only. Products on this website are intended solely for in-vitro research. They are not medicines, have not been evaluated by the FDA, and are not intended to diagnose, treat, cure, or prevent any disease. Any administration to humans or animals is strictly prohibited.
What are these peptides made for?
Our peptides are produced exclusively for laboratory and scientific research purposes.
Licensed Peptides™ products are developed using industry-standard synthesis and purification protocols, making them suitable for in vitro research, analytical testing, and experimental models.
Research-grade standards
- Synthesized via Solid Phase Peptide Synthesis (SPPS)
- Purified using advanced HPLC methods
- Verified through analytical quality control processes
- Screened for heavy metals and endotoxins
Consistency across batches
Strict process controls ensure reproducibility, allowing researchers to work with confidence across experiments.
Applications
Our peptides are commonly used in research involving:
- Cellular signaling pathways
- Tissue remodeling and repair mechanisms
- Extracellular matrix regulation
- Molecular biology and biochemical studies
All products are intended for research use only and are not for human or animal consumption, therapeutic use, or clinical application.
Why buy from Licensed Peptides
At Licensed Peptides™, quality isn’t a claim — it’s a controlled, repeatable process.
Every peptide we produce follows a strict, pharma-grade workflow designed to ensure purity, stability, and consistency from synthesis to delivery.
What sets us apart
ISO-certified cleanroom manufacturing
All peptides are synthesized in sterile, controlled environments to eliminate contamination risk and ensure batch consistency.
>99% verified purity (HPLC tested)
We use advanced High-Performance Liquid Chromatography (HPLC) to separate and verify peptide purity with precision.
Comprehensive safety testing
Each batch undergoes heavy metal and endotoxin screening to ensure it is free from hidden contaminants.
Pharma-grade raw materials
We start with rigorously tested amino acids and reagents, ensuring integrity at the molecular level.
Lyophilized for stability
Freeze-dried peptides maintain long-term stability, potency, and reliability for research applications.
Nitrogen-sealed vials
Every vial is protected from oxygen and moisture, preserving structural integrity during storage and transit.
Built for serious research
From synthesis to delivery, every step is engineered to meet the expectations of professionals who require accuracy, consistency, and reliability.
For laboratory research use only. Not for human or veterinary use.
How orders ship
We understand that timing and product integrity are critical for research.
| Ships to | United States (including minor outlying islands) |
|---|---|
| Processing days | Monday to Friday, excluding holidays |
| Daily cut-off | Paid orders placed before 4:00 PM PST are typically shipped the same business day |
| Free shipping | FedEx 2-Day Express on orders over $200 and for VIP members |
| Standard | USPS Ground Advantage, 3–7 business days (not guaranteed) — $8.95 |
| Expedited | FedEx 2-Day $11.95 · UPS 2-Day $19.95 · FedEx Next Day $44.99 |
| Signature | Required on delivery for orders of $1,000 or more |
How orders are handled
Cold chain protection
Products are stored in industrial-grade freezers prior to shipment to maintain stability and purity.
Secure & protective packaging
Each order is carefully packed to protect against temperature fluctuations, moisture exposure, and physical damage during transit.
Tracking
Once your order has shipped you will receive a tracking number by email, so you can monitor delivery progress.
Shipped from the United States
Orders are dispatched domestically from a U.S.-based operation, so there are no international customs steps.
Delivery times
Shipping times are estimates and begin after order processing. Delays may occur due to carrier issues, weather, or other unforeseen factors, and delivery dates are not guaranteed. Full terms are in our Shipping & Delivery Policy.
For laboratory research use only. Not for human or veterinary use.
Additional information
| pack | 1 pack, 3 pack, 5 pack, 10 pack |
|---|
Storage conditions at a glance
| Lyophilized, in transit | Stable for shipping for up to 3–4 months |
|---|---|
| Lyophilized, short term | Room temperature is usually adequate for several weeks; refrigeration under 4°C (39°F) is generally acceptable |
| Lyophilized, long term | Freezer at -80°C (-112°F) for several months to years |
| After reconstitution | Refrigerated; stable for up to 30 days |
| Light and moisture | Keep cold and away from light in the original sealed vial |
Why the powder is stable
All of our products are manufactured using the lyophilization (freeze drying) process, which keeps them stable for shipping for up to 3–4 months.
Lyophilization is a unique dehydration process, also known as cryodesiccation, where the peptides are frozen and then subjected to low pressure. This causes the water in the peptide vial to sublimate directly from solid to gas, leaving behind a stable, crystalline white structure known as lyophilized peptide. The puffy white powder can be stored at room temperature until it is reconstituted with bacteriostatic water.
Storing vials on arrival
Once peptides have been received, it is imperative that they are kept cold and away from light. If the peptides will be used in the next several days, weeks or months, short-term refrigeration under 4°C (39°F) is generally acceptable. Lyophilized peptides are usually stable at room temperatures for several weeks or more, so if they will be utilized within weeks or months such storage is typically adequate.
For longer term storage (several months to years) it is more preferable to store peptides in a freezer at -80°C (-112°F). When storing peptides for months or even years, freezing is optimal in order to preserve the peptide’s stability.
After reconstitution
Once the peptides are reconstituted with bacteriostatic water, they must be stored in the fridge to maintain stability. After reconstitution, the peptides will remain stable for up to 30 days.
For laboratory research use only. Not for human or veterinary use.
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