GHK-Cu 50mg
$59.99
GHK-Cu is an endogenous peptide naturally present in human plasma, urine, and saliva. Preclinical studies in animal models indicate that GHK-Cu enhances wound repair, supports immune function, and promotes skin regeneration by stimulating collagen synthesis, activating fibroblasts, and facilitating angiogenesis. Evidence also suggests that it functions as a feedback signal released following tissue injury. Additionally, GHK-Cu exhibits antioxidant properties by mitigating free radical–induced damage.
$59.99
$59.99
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Overview
GHK-Cu is a naturally occurring peptide found in plasma, urine, and saliva. Studies suggest it promotes wound healing, immune function, and skin regeneration by stimulating collagen production, fibroblasts, and angiogenesis. It also acts as a tissue injury–related feedback signal and exhibits antioxidant activity by reducing free radical damage.
GHK-Cu : Structure
Sequence: Gly-His-Lys·Cu·xHAc
Molecular Formula: C14H23CuN6O4
Molecular Weight: 401.91 g/mol
PubChem CID: 73587
CAS Number: 89030-95-5
Source: PubChem
GHK-Cu : Research
Wound Healing & Tissue Remodeling
- Enhances collagen (types I, III, IV, VII) and glycosaminoglycan (dermatan sulfate, chondroitin sulfate) synthesis; stimulates decorin—a key proteoglycan for ECM structure.
- Acts as a chemoattractant, drawing macrophages, mast cells, and capillary/endothelial cells to injury sites
- Promotes angiogenesis via upregulation of VEGF and bFGF, and enhances proliferation of endothelial cells (HUVECs)
- Animal studies demonstrate accelerated healing in rats, rabbits, mice, and pigs: faster wound closure, granulation tissue, angiogenesis, and reduced inflammatory markers (e.g., TNF-α, MMPs)
- A synergy with hyaluronic acid (HA) was shown: when combined at a 1:9 ratio, GHK-Cu + low-molecular-weight HA boosted collagen IV synthesis by 25× in fibroblasts and 2× in ex vivo skin models
GHK-Cu and Bacterial Infections
One of the major challenges in wound healing is the invasion of tissue by pathogenic microorganisms, which can significantly delay or prevent repair. Bacterial and fungal infections are particularly problematic in burn patients and individuals with compromised immune function (e.g., diabetes, HIV). When combined with specific fatty acids, GHK-Cu forms a potent antimicrobial complex effective against a range of bacteria and fungi that commonly impair wound healing.
Clinical research in diabetic patients has demonstrated that GHK-Cu outperforms standard care regimens in the treatment of diabetic ulcers. Patients receiving both standard care and GHK-Cu exhibited approximately a 40% increase in wound closure and a 27% reduction in infection rates compared to controls. Comparable benefits were also observed in patients with ischemic open wounds.
GHK-Cu and Pain Reduction
Preclinical studies in rats demonstrate that GHK-Cu produces dose-dependent analgesic effects, partly through elevating endogenous pain-modulating amino acids such as L-lysine and L-arginine. These findings suggest potential for non-opioid, non-NSAID approaches to pain management, avoiding the adverse cardiovascular and addictive risks associated with conventional therapies. GHK-Cu shows minimal side effects and good oral and subcutaneous bioavailability in animal models, though dosing data in rodents cannot be directly extrapolated to humans.
GHK – Cu : Scientific Journal & Authors
Loren Pickart, Ph.D., has authored over 100 publications and is actively developing patents related to GHK. His work includes investigations into the peptide’s impact on the expression of more than 4,000 human genes. Beyond its reported applications in skin inflammation, metastatic cancer, and COPD, GHK also shows potential benefits for the nervous, gastrointestinal, and mitochondrial systems. In his autobiography, Dr. Pickart outlines the motivations and background that shaped his lifelong focus on skin biology, anti-aging research, and regenerative science.
Referenced Citations
GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration
Effects of Tripeptide Gly-His-Lys in Pain-Induced Aggressive-Defensive Behavior in Rats
ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.
The products available on this website are intended solely for in-vitro research purposes (Latin: “in glass”), meaning they are used in experiments conducted outside a living organism. These products are not medicines or drugs, have not been evaluated or approved by the U.S. Food and Drug Administration (FDA), and are not intended to diagnose, treat, cure, or prevent any disease or medical condition. Any administration to humans or animals, whether by ingestion, injection, or other means, is strictly prohibited by law.
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Storage Instructions:
All of our products are manufactured using the Lyophilization (Freeze Drying) process, which ensures that our products remain 100% stable for shipping for up to 3-4 months.
Once the peptides are reconstituted (mixed with bacteriostatic water), they must be stored in the fridge to maintain stability. After reconstitution, the peptides will remain stable for up to 30 days.
Lyophilization is a unique dehydration process, also known as cryodesiccation, where the peptides are frozen and then subjected to low pressure. This causes the water in the peptide vial to sublimate directly from solid to gas, leaving behind a stable, crystalline white structure known as lyophilized peptide. The puffy white powder can be stored at room temperature until you’re ready to reconstitute it with bacteriostatic water.
Once peptides have been received, it is imperative that they are kept cold and away from light. If the peptides will be used immediately, or in the next several days, weeks or months, short-term refrigeration under 4C (39F) is generally acceptable. Lyophilized peptides are usually stable at room temperatures for several weeks or more, so if they will be utilized within weeks or months such storage is typically adequate.
However, for longer term storage (several months to years) it is more preferable to store peptides in a freezer at -80C (-112F). When storing peptides for months or even years, freezing is optimal in order to preserve the peptide’s stability.
For further information on proper storage techniques, click the link below: