GLP2-T 10mg

Regulatory History & Indications

May 13, 2022: FDA approval of Mounjaro (tirzepatide) for adults with type 2 diabetes, to complement diet and exercise.

November 2023: Expanded approval under the brand Zepbound for chronic weight management—including for obesity or overweight adults with at least one weight-related comorbidity.

Additionally, the UK regulator authorized Mounjaro for weight management in November 2023, and later, Zepbound for obstructive sleep apnea in 2024

Efficacy in Type 2 Diabetes (SURPASS Program)

SURPASS-1 (Placebo-controlled)

Over 40 weeks, tirzepatide (5–15 mg weekly) significantly reduced HbA₁c (by ~1.9–2.1%) versus placebo, and induced 7–9.5 kg weight loss. A striking percentage of participants reached HbA₁c targets of <7%, <6.5%, and even <5.7%, with minimal hypoglycemia and mostly mild GI side effects. The LancetScienceDirect

SURPASS-2 (vs. Semaglutide 1 mg)

In this 40-week open-label comparator, tirzepatide demonstrated superior glycemic control and weight loss:

HbA₁c reductions: up to –2.46% (15 mg) vs. –1.86% (semaglutide)

Mean weight loss: up to –12.4 kg vs. –6.2 kg

Higher proportions achieved HbA₁c <7% and <5.7%

Side effects again primarily mild-to-moderate GI symptoms. New England Journal of MedicineLilly

Overall SURPASS Findings

Tirzepatide provided greater HbA₁c reductions (1.87–3.02%) and weight reductions (5.4–12.9 kg), outperforming placebo, semaglutide, dulaglutide, and basal insulins across global cohorts and durations up to 104 weeks. Benefits extended to cardiometabolic parameters: blood pressure, lipids, liver fat, and albuminuria. PubMed

Tirzepatide : Structure

Amino Acid Sequence: YE-Aib-GTFTSDYSI-Aib-LDKIAQ (C20 fatty acid) AFVQWLIAGGPSSGAPPPS
Note: Aib is a non-coded (non-proteinogenic) amino acid – H₂H-C(CH₃)₂-COOH
Molecular Formula: C₂₂₅H₃₄₈N₄₈O₆₈
Molecular Weight: 4813.527 g/mol
PubChem CID: 156588324
CAS Number: 2023788-19-2
Synonyms: Tirzepatide, P1206, LY3298176, Dual GIP and GLP-1 receptor agonist (GIP/GLP-1RA)

Source: PubChem

 

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The products available on this website are intended solely for in-vitro research purposes (Latin: “in glass”), meaning they are used in experiments conducted outside a living organism. These products are not medicines or drugs, have not been evaluated or approved by the U.S. Food and Drug Administration (FDA), and are not intended to diagnose, treat, cure, or prevent any disease or medical condition. Any administration to humans or animals, whether by ingestion, injection, or other means, is strictly prohibited by law.

 

 

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Storage Instructions:

All of our products are manufactured using the Lyophilization (Freeze Drying) process, which ensures that our products remain 100% stable for shipping for up to 3-4 months.

Once the peptides are reconstituted (mixed with bacteriostatic water), they must be stored in the fridge to maintain stability. After reconstitution, the peptides will remain stable for up to 30 days.

Lyophilization is a unique dehydration process, also known as cryodesiccation, where the peptides are frozen and then subjected to low pressure. This causes the water in the peptide vial to sublimate directly from solid to gas, leaving behind a stable, crystalline white structure known as lyophilized peptide. The puffy white powder can be stored at room temperature until you’re ready to reconstitute it with bacteriostatic water.

Once peptides have been received, it is imperative that they are kept cold and away from light. If the peptides will be used immediately, or in the next several days, weeks or months, short-term refrigeration under 4C (39F) is generally acceptable. Lyophilized peptides are usually stable at room temperatures for several weeks or more, so if they will be utilized within weeks or months such storage is typically adequate.

However, for longer term storage (several months to years) it is more preferable to store peptides in a freezer at -80C (-112F). When storing peptides for months or even years, freezing is optimal in order to preserve the peptide’s stability.

For further information on proper storage techniques, click the link below:

Peptide Storage