Ipamorelin 10mg
$59.99
Ipamorelin is a synthetic pentapeptide originally developed by Novo Nordisk as part of their exploration of selective growth hormone secretagogues. Structurally, it is a short chain of five amino acids, designed to act as an agonist at the ghrelin or growth hormone secretagogue receptor (GHS-R1a). By binding to this receptor in the hypothalamus and pituitary gland, ipamorelin mimics the activity of the natural “hunger hormone” ghrelin, stimulating the pituitary to release growth hormone (GH) in a pulsatile and physiologically natural rhythm. This mechanism contrasts with direct growth hormone injections, which deliver GH in a non-pulsatile, supra-physiological manner.
$59.99
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Overview
Ipamorelin is a synthetic pentapeptide developed as a potent growth hormone (GH) secretagogue. It stimulates GH release both in vitro and in vivo with similar effectiveness to GHRP-6 but shows remarkable selectivity. Unlike other GH secretagogues such as GHRP-2 and GHRP-6, ipamorelin does not increase cortisol or ACTH levels, even at very high doses, and has no effect on other pituitary hormones like FSH, LH, prolactin, or TSH. This unique profile makes it the first GHRP-receptor agonist to display GH selectivity comparable to that of natural GHRH, highlighting its potential for future clinical development.
Ipamorelin : Structure
Peptide Sequence: Aib-His-D-2Nal-D-Phe-Lys
Molecular Formula: C₃₈H₄₉N₉O₅
Molecular W: 9831659
CAS Number: 170851-70-4
Source: PubChem
Ipamorelin: Research
Ghrelin Receptor
The ghrelin receptor, a 7-transmembrane protein, is found at elevated levels in certain cancers and in heart failure, making it a valuable biomarker for imaging applications. Past PET tracers have mostly been limited to small-molecule quinalizonones and ghrelin-derived peptides. In this work, a new set of 4-fluorobenzoylated growth hormone secretagogues (GHSs) was designed and tested, spanning both peptide-based (GHRP-1, GHRP-2, GHRP-6) and peptidomimetic (G-7039, [1-Nal4]G-7039, ipamorelin) structures. The peptidomimetic analogue G-7039 proved to be the most promising scaffold for fluorine-18 incorporation. Its modified derivative, [1-Nal4,Lys5(4-FB)]G-7039, showed strong receptor affinity (IC50 = 69 nM) and potent in vitro activity (EC50 = 1.1 nM). Using N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB) for labeling, the radiotracer [1-Nal4,Lys5(4-[18F]-FB)]G-7039 was obtained with high yield (48%), excellent purity (≥99%), and good molar activity (>34 GBq/μmol). This radiolabeled compound represents a strong candidate for PET imaging of diseases linked to ghrelin receptor overexpression.
Ipamorelin-Induced Insulin Secretion in Normal and Diabetic Rats
Administration of ipamorelin elicited a statistically significant increase (p<0.04) in pancreatic insulin secretion in both normoglycemic and diabetic rats. This stimulatory effect was markedly attenuated (p<0.03) following pretreatment with diltiazem, yohimbine, propranolol, or a combined regimen of atropine, propranolol, and yohimbine. Notably, atropine administration produced a significant reduction (p<0.007) in ipamorelin-induced insulin secretion in diabetic rats, whereas no such effect was observed in normoglycemic counterparts.
Protective Role of Ipamorelin in Glucocorticoid-Compromised Bone Formation
The study evaluated whether the growth hormone secretagogue ipamorelin could mitigate glucocorticoid-induced muscle and bone deterioration in adult rats. Eight-month-old female rats received daily methylprednisolone (9 mg/kg), ipamorelin (100 µg/kg, three times daily), or a combination of both for three months. Muscle strength was assessed via in vivo measurement of calf muscle tetanic tension, and bone formation was evaluated by periosteal activity. Co-administration of ipamorelin with glucocorticoids significantly improved maximum tetanic muscle force and enhanced periosteal bone formation—approximately four times greater than glucocorticoid treatment alone. These findings indicate that ipamorelin effectively counteracts glucocorticoid-induced declines in skeletal muscle strength and bone formation.
Referenced Citations
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The products available on this website are intended solely for in-vitro research purposes (Latin: “in glass”), meaning they are used in experiments conducted outside a living organism. These products are not medicines or drugs, have not been evaluated or approved by the U.S. Food and Drug Administration (FDA), and are not intended to diagnose, treat, cure, or prevent any disease or medical condition. Any administration to humans or animals, whether by ingestion, injection, or other means, is strictly prohibited by law.
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Storage Instructions:
All of our products are manufactured using the Lyophilization (Freeze Drying) process, which ensures that our products remain 100% stable for shipping for up to 3-4 months.
Once the peptides are reconstituted (mixed with bacteriostatic water), they must be stored in the fridge to maintain stability. After reconstitution, the peptides will remain stable for up to 30 days.
Lyophilization is a unique dehydration process, also known as cryodesiccation, where the peptides are frozen and then subjected to low pressure. This causes the water in the peptide vial to sublimate directly from solid to gas, leaving behind a stable, crystalline white structure known as lyophilized peptide. The puffy white powder can be stored at room temperature until you’re ready to reconstitute it with bacteriostatic water.
Once peptides have been received, it is imperative that they are kept cold and away from light. If the peptides will be used immediately, or in the next several days, weeks or months, short-term refrigeration under 4C (39F) is generally acceptable. Lyophilized peptides are usually stable at room temperatures for several weeks or more, so if they will be utilized within weeks or months such storage is typically adequate.
However, for longer term storage (several months to years) it is more preferable to store peptides in a freezer at -80C (-112F). When storing peptides for months or even years, freezing is optimal in order to preserve the peptide’s stability.
For further information on proper storage techniques, click the link below: