Kisspeptin-10 10mg

Overview

Kisspeptin-10 is a short synthetic peptide fragment derived from the naturally occurring kisspeptin protein, which is encoded by the KISS1 gene. Kisspeptin peptides are potent activators of the G-protein coupled receptor GPR54 (also called KISS1R), a receptor essential for regulating reproductive hormone secretion.

Kisspeptin-10 represents the biologically active core sequence of the full-length peptide and retains its ability to stimulate the hypothalamic–pituitary–gonadal (HPG) axis, leading to the release of gonadotropin-releasing hormone (GnRH), and subsequently luteinizing hormone (LH) and follicle-stimulating hormone (FSH).

Kisspeptin-10 : Structure

Sequence: YNWNSFGLRF
Molecular Formula: C₆₃H₈₃N₁₇O₁₄
Molecular Weight: 1302.4 g/mol
PubChem CID: 25240297
Synonyms: KISS-1, Protein KISS-1, metastin, Kp-10 peptide

Source: PubChem

Kisspeptin-10: Research

Area of Study: Reproductive Hormone Regulation

Key Findings:
Kisspeptin stimulates GnRH release, which drives LH and FSH secretion, establishing it as a central regulator of the hypothalamic–pituitary–gonadal (HPG) axis.

References:
Oakley et al., 2009; Clarkson & Herbison, 2006

Area of Study: Puberty Initiation

Key Findings:
Mutations in KISS1 or KISS1R (GPR54) lead to delayed/absent puberty (hypogonadotropic hypogonadism), confirming its critical role in sexual maturation.

References:
Seminara et al., 2003; d’Anglemont de Tassigny & Colledge, 2010

Area of Study: Fertility & Infertility

Key Findings:
Kisspeptin triggers oocyte maturation and has been tested in IVF as a safer alternative to hCG, reducing risk of ovarian hyperstimulation syndrome.

References:
Jayasena et al., 2014; Abbara et al., 2015

Area of Study: Testosterone & Estrogen Modulation

Key Findings:
Clinical studies show kisspeptin increases LH and gonadal steroid hormones (testosterone in men, estradiol in women).

References:
Dhillo et al., 2005; George et al., 2011

Area of Study: Sexual Behavior & Motivation

Key Findings:
fMRI and behavioral studies demonstrate kisspeptin enhances limbic brain activity linked to sexual and emotional processing.

References:
Comninos et al., 2017

Area of Study: Aging & Reproductive Decline

Key Findings:
Kisspeptin signaling declines with age; experimental work suggests supplementation may restore aspects of reproductive hormone function.

References:
Ramaswamy et al., 2011

Area of Study: Metabolic Effects

Key Findings:
Emerging evidence indicates kisspeptin may interact with metabolic pathways, influencing energy balance and insulin sensitivity.

References:
Tolson et al., 2014

Increasing Testosterone

Kisspeptin influences testosterone production indirectly by regulating circulating levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Its effects appear to be sex-specific: in men, kisspeptin significantly elevates testosterone, whereas in women it shows little to no effect on testosterone levels.

In one clinical study, six men received an intravenous dose of a kisspeptin derivative, resulting in nearly a threefold increase in plasma testosterone within 90 minutes (Dhillo et al., 2005). Another analog of kisspeptin has been shown to modify the pulsatile frequency of LH release in men, suggesting a role in fine-tuning the normal rhythm of reproductive hormone secretion (George et al., 2011).

Further research demonstrated that administration of Kisspeptin-10 in healthy men produced a rapid, dose-dependent rise in serum LH, accompanied by a corresponding increase in testosterone (Dhillo et al., 2005; George et al., 2011). This effect is attributed to kisspeptin’s ability to enhance the pulsatile release of LH. However, when administered at high doses, kisspeptin-10 can induce such rapid LH pulses that individual fluctuations become indistinguishable, leading to a state of continuous LH release.

These findings highlight the therapeutic potential of kisspeptin and its analogues for conditions involving reproductive hormone regulation, including infertility, hypogonadism, low testosterone levels, and pregnancy-related disorders.

Effect on Mood

Just as reproduction and energy levels are linked, reproduction and emotions are also closely connected. Since kisspeptin plays a role in both reproduction and energy balance, researchers explored how this peptide might affect emotions and behavior. To investigate, they compared the effects of kisspeptin versus a placebo in a study involving 29 healthy heterosexual men. Those who received kisspeptin showed increased activity in the limbic region of the brain, which is associated with emotions. Specifically, they exhibited greater reward-seeking behavior, heightened drive, and an overall improvement in mood.

These results suggest that kisspeptin may help integrate sexual and emotional brain processes with the broader reproductive system. This insight deepens our understanding of how mood, motivation, and drive are connected not only to sexuality, but also to human behavior more generally.

Kidney and Heart

While kisspeptin is well known for its role in reproduction and hormone regulation, it may come as a surprise that it also plays a role in kidney function. Kisspeptin and its receptors are present in various parts of the kidney, where they are thought to influence kidney signaling. Studies in mice lacking the Kiss1 receptor have shown that kisspeptin is crucial for proper glomerular development during kidney formation. However, the specific mechanisms behind this, whether direct or indirect, are still unclear and need further investigation.

Although the precise function of kisspeptin in the kidney is still being studied, it likely ties into its broader role in regulating vascular development and the body’s response to injury. Research on cardiovascular disease in mice indicates that kisspeptin may affect certain blood vessels, influencing vasoconstriction and even cardiac output under specific conditions. Kisspeptin’s role in both kidney and heart health seems linked to its impact on blood vessel formation (angiogenesis) and vascular function. Interestingly, this same mechanism may contribute to its ability to reduce tumor metastasis. Gaining a deeper understanding of how kisspeptin operates in the vascular system could pave the way for its use in new therapeutic approaches.

Referenced Citations

Dhillo, W.S. et al. (2005). Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males. Journal of Clinical Endocrinology & Metabolism, 90(12), 6609–6615.

Moshmi Bhattacharya, Andy V. Babwah, Kisspeptin: Beyond the Brain, Endocrinology, Volume 156, Issue 4, 1 April 2015, Pages 1218–1227, https://doi.org/10.1210/en.2014-1915.

Kisspeptin modulates sexual and emotional brain processing in humans.

 

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The products available on this website are intended solely for in-vitro research purposes (Latin: “in glass”), meaning they are used in experiments conducted outside a living organism. These products are not medicines or drugs, have not been evaluated or approved by the U.S. Food and Drug Administration (FDA), and are not intended to diagnose, treat, cure, or prevent any disease or medical condition. Any administration to humans or animals, whether by ingestion, injection, or other means, is strictly prohibited by law.

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Storage Instructions:

All of our products are manufactured using the Lyophilization (Freeze Drying) process, which ensures that our products remain 100% stable for shipping for up to 3-4 months.

Once the peptides are reconstituted (mixed with bacteriostatic water), they must be stored in the fridge to maintain stability. After reconstitution, the peptides will remain stable for up to 30 days.

Lyophilization is a unique dehydration process, also known as cryodesiccation, where the peptides are frozen and then subjected to low pressure. This causes the water in the peptide vial to sublimate directly from solid to gas, leaving behind a stable, crystalline white structure known as lyophilized peptide. The puffy white powder can be stored at room temperature until you’re ready to reconstitute it with bacteriostatic water.

Once peptides have been received, it is imperative that they are kept cold and away from light. If the peptides will be used immediately, or in the next several days, weeks or months, short-term refrigeration under 4C (39F) is generally acceptable. Lyophilized peptides are usually stable at room temperatures for several weeks or more, so if they will be utilized within weeks or months such storage is typically adequate.

However, for longer term storage (several months to years) it is more preferable to store peptides in a freezer at -80C (-112F). When storing peptides for months or even years, freezing is optimal in order to preserve the peptide’s stability.

For further information on proper storage techniques, click the link below:

Peptide Storage