MOTS-c 10mg
$74.99
MOTS-c is a 16–amino acid mitochondrial-derived peptide (MDP) that plays a key role in metabolic regulation. Produced within mitochondria, it helps maintain cellular energy balance by influencing glucose metabolism, insulin sensitivity, and stress-response pathways. MOTS-c can translocate to the nucleus, where it regulates the expression of genes involved in mitochondrial biogenesis and metabolic adaptation, particularly during metabolic stress. Studies indicate that MOTS-c enhances exercise performance, reduces obesity and insulin resistance, and provides protective effects against conditions such as osteoporosis, metabolic disorders, and age-related diseases.
In summary, MOTS-c supports metabolic homeostasis, healthy aging, and improved physical performance while mitigating the risk of obesity, insulin resistance, and related disease states.
$74.99
$74.99
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Overview
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16–amino acid mitochondrial-derived peptide (MDP) encoded within the mitochondrial 12S rRNA gene. It is synthesized in mitochondria but can translocate to the nucleus under conditions of metabolic stress, where it regulates nuclear gene expression involved in mitochondrial biogenesis, glucose utilization, and metabolic adaptation.
Functionally, MOTS-c plays a critical role in regulating energy balance, glucose metabolism, insulin sensitivity, and stress-response pathways. Research demonstrates that MOTS-c enhances exercise capacity, improves insulin signaling, reduces obesity, and supports bone health. Beyond these metabolic effects, it also provides protection against age-associated disorders, including osteoporosis and metabolic syndrome.
Because of these properties, MOTS-c is considered a promising therapeutic candidate for obesity, type 2 diabetes, osteoporosis, and age-related metabolic decline, with potential contributions to promoting healthspan and longevity.
MOTS-c: Structure
Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
Molecular Formula: C₁₀₆H₁₇₅N₃₁O₃₂S₂
Molecular Weight: 2174.64 g/mol
PubChem SID: 255386757
CAS Number: 1627580-64-6
Synonyms: Mitochondrial open reading frame of the 12S rRNA-c, MT-RNR1
Source: Wikipedia
MOTS-c: Research
Aging, Stem Cell Homeostasis & Nuclear Gene Regulation
In aged human placenta-derived mesenchymal stem cells (hPD-MSCs), MOTS-c improved cellular morphology, activated AMPK, inhibited mTORC1, reduced oxygen consumption and ROS production, and decreased lipid synthesis—collectively restoring mitochondrial homeostasis similar to younger cells.
A comprehensive review highlighted that MOTS-c levels decline with age. It can translocate to the nucleus during metabolic stress to regulate gene transcription. MOTS-c has beneficial effects on age-related diseases, including diabetes, cardiovascular diseases, osteoporosis, obesity, and Alzheimer’s, and is linked to promoting healthy aging.
Aging-Associated Decline & Lifespan Relevance
MOTS-c levels decline with age in humans (e.g., ~21% reduction in 70–81-year-olds compared to 18–30 groups). Through its metabolic and nuclear regulatory effects, MOTS-c may counteract aging-related decline in energy metabolism and physical capacity.
Osteoporosis
MOTS-c has been shown to influence bone health by enhancing the synthesis of type I collagen in osteoblasts. Studies in osteoblast cell lines indicate that MOTS-c modulates the TGF-β/SMAD signaling pathway, which is essential for osteoblast survival and function. By supporting osteoblast viability, MOTS-c contributes to increased type I collagen production, thereby strengthening bone structure and integrity.
Further research has demonstrated that MOTS-c also promotes the differentiation of bone marrow stem cells into osteoblasts through the same TGF-β/SMAD pathway. This process leads to greater osteogenesis (new bone formation). Thus, MOTS-c not only protects osteoblasts and enhances their survival, but also facilitates the development of new bone-forming cells from stem cell populations.
Referenced Citations
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The products available on this website are intended solely for in-vitro research purposes (Latin: “in glass”), meaning they are used in experiments conducted outside a living organism. These products are not medicines or drugs, have not been evaluated or approved by the U.S. Food and Drug Administration (FDA), and are not intended to diagnose, treat, cure, or prevent any disease or medical condition. Any administration to humans or animals, whether by ingestion, injection, or other means, is strictly prohibited by law.
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Storage Instructions:
All of our products are manufactured using the Lyophilization (Freeze Drying) process, which ensures that our products remain 100% stable for shipping for up to 3-4 months.
Once the peptides are reconstituted (mixed with bacteriostatic water), they must be stored in the fridge to maintain stability. After reconstitution, the peptides will remain stable for up to 30 days.
Lyophilization is a unique dehydration process, also known as cryodesiccation, where the peptides are frozen and then subjected to low pressure. This causes the water in the peptide vial to sublimate directly from solid to gas, leaving behind a stable, crystalline white structure known as lyophilized peptide. The puffy white powder can be stored at room temperature until you’re ready to reconstitute it with bacteriostatic water.
Once peptides have been received, it is imperative that they are kept cold and away from light. If the peptides will be used immediately, or in the next several days, weeks or months, short-term refrigeration under 4C (39F) is generally acceptable. Lyophilized peptides are usually stable at room temperatures for several weeks or more, so if they will be utilized within weeks or months such storage is typically adequate.
However, for longer term storage (several months to years) it is more preferable to store peptides in a freezer at -80C (-112F). When storing peptides for months or even years, freezing is optimal in order to preserve the peptide’s stability.
For further information on proper storage techniques, click the link below: