PT-141 10mg

Overview

PT-141, clinically known as Bremelanotide, is a synthetic peptide and pharmacological agent derived from alpha-melanocyte-stimulating hormone (α-MSH). Unlike its parent compound, it has been structurally modified to enhance receptor selectivity and stability.

Mechanism of Action:

PT-141 acts primarily as an agonist of the melanocortin-4 receptor (MC4R) and, to a lesser extent, the melanocortin-1 receptor (MC1R). Activation of MC4R in the central nervous system is linked to sexual arousal pathways, while MC1R contributes to pigmentation and immune regulation.

Therapeutic Applications:

The peptide has been evaluated extensively for the treatment of hypoactive sexual desire disorder (HSDD) in both men and women. Unlike phosphodiesterase-5 inhibitors (e.g., sildenafil), which act on the vascular system, PT-141 influences neurogenic pathways of sexual desire and arousal. Clinical studies have also explored its use in acute hemorrhagic conditions due to its hemodynamic effects.

PT- 141 : Structure

Peptide Sequence: Ac-Nle-Asp(1)-His-D-Phe-Arg-Trp-Lys(1)
Molecular Formula: C₅₀H₆₈N₁₄O₁₀
Molecular Weight: 1025.182 g/mol
PubChem CID: 9941379
CAS Number: 189691-06-3

Source: PubChem

PT-141 : Research

PT-141 (Bremelanotide) and Sexual Arousal

PT-141 (bremelanotide) is a synthetic peptide that functions as an agonist of the melanocortin-4 receptor (MC4R), a receptor known to regulate sexual arousal within the central nervous system. Preclinical studies in animal models have demonstrated that MC4R activation enhances sexual motivation and increases copulatory behavior in both male and female subjects.

Unlike phosphodiesterase type 5 (PDE5) inhibitors such as sildenafil (Viagra), which primarily act on peripheral vascular pathways to improve penile blood flow, PT-141 acts centrally through neuroendocrine mechanisms. This distinction enables PT-141 to address sexual arousal disorders in men and women that are not attributable solely to vascular insufficiency.

Clinical research further supports its potential: in a study involving men with erectile dysfunction (ED) unresponsive to sildenafil, approximately one-third achieved satisfactory erections for sexual intercourse following administration of intranasal PT-141. The study also revealed a clear dose-dependent relationship, reinforcing the efficacy of PT-141 in selected cases.

These findings suggest that PT-141 may provide therapeutic benefit for both erectile dysfunction resistant to PDE5 inhibitors and central causes of hypoactive sexual desire, highlighting its unique role as a centrally acting treatment for sexual dysfunction.

PT-141 and Infection

Preclinical research indicates that activation of the melanocortin-1 receptor (MC1R), which is one of the receptor targets of PT-141, demonstrates notable antifungal and anti-inflammatory properties in a rat model of fungal infection. This finding is significant because currently available antifungal agents are limited by their mechanisms of action and are frequently associated with serious, treatment-limiting adverse effects. The identification of alternative therapeutic pathways, such as those mediated by MC1R activation, could therefore represent an important advancement in managing fungal infections. Such an approach may ultimately reduce morbidity and mortality, particularly in immunocompromised populations, where fungal infections are often severe and difficult to treat.

Referenced Citations

The Synthetic Melanocortin (CKPV)2 Exerts Anti-Fungal and Anti-Inflammatory Effects against Candida albicans Vaginitis via Inducing Macrophage M2 Polarization

Wessells H, Hruby VJ, Hackett J, Han G, Balse-Srinivasan P, Vanderah TW. Ac-Nle-c[Asp-His-DPhe-Arg-Trp-Lys]-NH2 induces penile erection via brain and spinal melanocortin receptors. Neuroscience. 2003;118(3):755-62. doi: 10.1016/s0306-4522(02)00866-7. PMID: 12710982.

 

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The products available on this website are intended solely for in-vitro research purposes (Latin: “in glass”), meaning they are used in experiments conducted outside a living organism. These products are not medicines or drugs, have not been evaluated or approved by the U.S. Food and Drug Administration (FDA), and are not intended to diagnose, treat, cure, or prevent any disease or medical condition. Any administration to humans or animals, whether by ingestion, injection, or other means, is strictly prohibited by law.

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Storage Instructions:

All of our products are manufactured using the Lyophilization (Freeze Drying) process, which ensures that our products remain 100% stable for shipping for up to 3-4 months.

Once the peptides are reconstituted (mixed with bacteriostatic water), they must be stored in the fridge to maintain stability. After reconstitution, the peptides will remain stable for up to 30 days.

Lyophilization is a unique dehydration process, also known as cryodesiccation, where the peptides are frozen and then subjected to low pressure. This causes the water in the peptide vial to sublimate directly from solid to gas, leaving behind a stable, crystalline white structure known as lyophilized peptide. The puffy white powder can be stored at room temperature until you’re ready to reconstitute it with bacteriostatic water.

Once peptides have been received, it is imperative that they are kept cold and away from light. If the peptides will be used immediately, or in the next several days, weeks or months, short-term refrigeration under 4C (39F) is generally acceptable. Lyophilized peptides are usually stable at room temperatures for several weeks or more, so if they will be utilized within weeks or months such storage is typically adequate.

However, for longer term storage (several months to years) it is more preferable to store peptides in a freezer at -80C (-112F). When storing peptides for months or even years, freezing is optimal in order to preserve the peptide’s stability.

For further information on proper storage techniques, click the link below:

Peptide Storage