99%+ Purity
Guaranteed per batch
4.9 847 verified reviews
Semax Nasal /30ml · 50mg
Total Price
$649.93
Discounted Price
$454.95
Packs
5 packs
You Save
$194.98
30% OFF
On Sale!
Retail Price
$597.54
Your Price
$597.54
Per vial: $42.58
You Save
$597.54
33% OFF
Select Packs
Bulk pricing applied
📈 Upgrade to 10 vials and save an extra vs. buying 5 — nearly 3 free vials.
Select Purchase Option:
-
99%+ HPLC Purity — Independently verified by accredited US laboratory -
Endotoxin-Screened — LAL tested, LPS-free, endotoxin report available
-
GMP-Certified Manufacturing — USA facility, ISO 9001:2015
-
Lyophilized for Stability — Shipped cold-packed, intact for reconstitution
Molecular Weight
Third Party Tested
APPLICATION
For Research Use only
Form
Lyophilized Powder
Storage
-20°C Long Term
Purity (HPLC)
99%+ Third Party Verified
Manufacture
USA / GMP
4.9 847 verified reviews
Semax Nasal /30ml · 50mg
Total Price
$649.93
Discounted Price
$454.95
Packs
5 packs
You Save
$194.98
30% OFF
Select Packs
Bulk pricing applied
📈 Upgrade to 10 vials and save an extra vs. buying 5 — nearly 3 free vials.
Select Purchase Option:
-
99%+ HPLC Purity —
Independently verified by accredited US laboratory
-
Endotoxin-Screened —
LAL tested, LPS-free, endotoxin report available
-
GMP-Certified Manufacturing —
USA facility, ISO 9001:2015
-
Lyophilized for Stability —
Shipped cold-packed, intact for reconstitution
Molecular Weight
Third Party Tested
APPLICATION
For Research Use only
Form
Lyophilized Powder
Storage
-20°C Long Term
Purity (HPLC)
99%+ Third Party Verified
Manufacture
USA / GMP
50mg per 30ml bottle - 250mcg per spray - 200 sprays per bottle
Semax is a synthetic peptide derived from the ACTH(4-10) fragment, widely studied for its effects on brain function and cognitive performance. Research suggests that Semax supports neuroplasticity, enhances learning and memory, and helps regulate dopamine levels. It also plays a role in maintaining oxidative balance and protecting neurons from stress, making it a promising compound for cognitive resilience and neuroprotection.
Semax works by influencing key neurotrophic pathways, including BDNF, TrkB, NGF, and GAP-43, which are critical for healthy brain signaling and neuronal growth. This combination of neuroprotective and nootropic effects has made Semax a focus of research in neurological health, cognitive enhancement, and recovery from brain injury.
Whether you’re exploring cutting-edge cognitive research or looking for ways to support brain health, Semax represents a fascinating area of study in modern neuroscience.
Overview
Semax, a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) derived from the ACTH(4-10) fragment, is widely studied for its neurotrophic and cognitive effects. It modulates key signaling pathways, including BDNF, TrkB, and transcription factors such as NGF and GAP-43, and has been shown to influence neuronal plasticity, dopaminergic function, and oxidative balance in the central nervous system.
Semax : Structure
Property and Descriptions:
Sequence: Met-Glu-His-Phe-Pro-Gly-Pro
Molecular Formula: C₃₇H₅₁N₉O₁₀S
Molecular Weight: 813.92 g/mol
CAS Number: 80714-61-0
Synonyms: Pro-Gly-Pro-ACTH
Source: PubChem
Selank : Research
Neurotrophic Gene Expression and Cognitive Function
Study: Effect of Semax on BDNF and NGF gene expression in the rat brain
This research evaluated how Semax influences expression of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) key proteins involved in synaptic plasticity, learning, and memory. Semax altered gene expression dynamics in hippocampus and frontal cortex shortly after a single administration, supporting mechanisms tied to cognitive enhancement.
Neuroprotection in Cerebral Ischemia (Stroke Models)
Study: Protective effects of Semax in rat cerebral ischemia-reperfusion
Using a transient middle cerebral artery occlusion (tMCAO) model, researchers found that Semax upregulated neuroprotective proteins (e.g., CREB) and downregulated inflammatory markers (e.g., MMP-9, JNK), suggesting molecular neuroprotection and reduced damage post-stroke.
Study: Gene expression changes in ischemic rat brain
A genome-wide study showed that Semax significantly modulated immune- and vascular-related gene expression after focal ischemia, implying immune and vascular system involvement in its neuroprotective effects.
Cellular Mechanisms and Neuron Physiology
Study: Semax effects on intracellular calcium dynamics
In hippocampal and cerebellar slice models, Semax changed spontaneous intracellular calcium fluctuations in neurons providing insight into early cellular signaling events relevant to neuroprotection and synaptic plasticity.
Vascular and Neurotrophin Regulation in Ischemia
Study: Effects of Semax on VEGFA and related genes
After global ischemia in rats, Semax reduced ischemia-induced increases in vascular endothelial growth factor (VEGFA) mRNA, suggesting modulation of vascular responses and possible anti-inflammatory effects alongside neurotrophic support.
Study: Semax impacts neurotrophin and receptor expression after ischemia
Semax influenced mRNA levels of key neurotrophins (NGF, BDNF, NT-3) and their receptors, especially in cortex and hippocampus highlighting its role in adaptation of neurotrophin systems after brain injury.
Referenced Citations
ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.
The products available on this website are intended solely for in-vitro research purposes (Latin: “in glass”), meaning they are used in experiments conducted outside a living organism. These products are not medicines or drugs, have not been evaluated or approved by the U.S. Food and Drug Administration (FDA), and are not intended to diagnose, treat, cure, or prevent any disease or medical condition. Any administration to humans or animals, whether by ingestion, injection, or other means, is strictly prohibited by law.
Research
Our peptides are produced exclusively for laboratory and scientific research purposes.
Licensed Peptides™ products are developed using industry-standard synthesis and purification protocols, making them suitable for in vitro research, analytical testing, and experimental models.
Research-Grade Standards
- Synthesized via Solid Phase Peptide Synthesis (SPPS)
- Purified using advanced HPLC methods
- Verified through analytical quality control processes
- Screened for heavy metals and endotoxins
Consistency Across Batches
Strict process controls ensure reproducibility, allowing researchers to work with confidence across experiments.
Applications
Our peptides are commonly used in research involving:
- Cellular signaling pathways
- Tissue remodeling and repair mechanisms
- Extracellular matrix regulation
- Molecular biology and biochemical studies
Important Notice
All products are intended for research use only and are not for human or animal consumption, therapeutic use, or clinical application.
Why Buy From Us
At Licensed Peptides™, quality isn’t a claim. it’s a controlled, repeatable process.
Every peptide we produce follows a strict, pharma-grade workflow designed to ensure purity, stability, and consistency from synthesis to delivery.
What sets us apart:
ISO-Certified Cleanroom Manufacturing
All peptides are synthesized in sterile, controlled environments to eliminate contamination risk and ensure batch consistency.
>99% Verified Purity (HPLC Tested)
We use advanced High-Performance Liquid Chromatography (HPLC) to separate and verify peptide purity with precision.
Comprehensive Safety Testing
Each batch undergoes heavy metal and endotoxin screening to ensure it is free from hidden contaminants.
Pharma-Grade Raw Materials
We start with rigorously tested amino acids and reagents, ensuring integrity at the molecular level.
Lyophilized for Stability
Freeze-dried peptides maintain long-term stability, potency, and reliability for research applications.
Nitrogen-Sealed Vials
Every vial is protected from oxygen and moisture, preserving structural integrity during storage and transit.
Built for Serious Research
From synthesis to delivery, every step is engineered to meet the expectations of professionals who require accuracy, consistency, and reliability.
Shipping
We understand that timing and product integrity are critical for research.
Same-Day Shipping (USA)
All in-stock orders placed before our daily cutoff are shipped the same day from within the United States.
Fast Domestic Delivery (1–3 Days)
We use expedited carriers to ensure your peptides arrive quickly and reliably nationwide.
Cold Chain Protection
Products are stored in industrial-grade freezers prior to shipment to maintain stability and purity.
Secure & Protective Packaging
Each order is carefully packed to protect against temperature fluctuations, moisture exposure, and physical damage during transit.
Real-Time Tracking
You’ll receive tracking information immediately upon shipment so you can monitor delivery progress.
Consistency You Can Rely On
No long international delays, no customs issues. Just fast, dependable delivery from a U.S.-based operation.
Additional information
| pack | 1 pack, 3 pack, 5 pack, 10 pack |
|---|
Storage:
Store in the original nasal spray container in a refrigerator at 2–8°C (36–46°F). Keep tightly closed when not in use. Protect from light, heat, and moisture. Do not freeze.
Handling Precautions:
Avoid excessive shaking or agitation. Keep the nozzle clean and replace the cap immediately after each use to prevent contamination.
Stability:
Utilize within the recommended timeframe after opening (commonly 30–60 days, depending on formulation and preservatives).
99%+ — Passes ≥99% 
Download Full COA / HPLC Report (PDF) 
99%+ Every Batch
Often Not Disclosed