SLU-PP-332 · 5mg

Proper storage helps preserve the integrity of research compounds and supports consistent laboratory results.

SLU-PP-332 is an emerging research compound in metabolic biology. As such, analytical quality and batch consistency are crucial so researchers can have a well-characterized compound suitable for laboratory analysis.

Here at Licensed PeptidesTM, we understand the importance of reliable research compounds; that’s why we use a 6-point process to verify quality:

I. A High-Performance Liquid Chromatography (HPLC) analysis to check for 99%+ purity

II. Mass spectrometry to confirm the molecular identity and structure of the compound.

III. Screening for heavy metals and endotoxins, including lipopolysaccharides (LPS)

IV. Verification of sterility through an ISO/IEC 17025:2017-accredited laboratory

V. Our team also confirms that the content (weight and concentration) is accurate

VI. Lastly, we physically inspect every product for packaging integrity, label accuracy, and overall appearance

The Discovery of SLU-PP-332

SLU-PP-332 was developed as part of ongoing research into estrogen-related receptors (ERRs). ERRs help regulate genes involved in cellular energy metabolism and mitochondrial function.

Earlier compounds like GSK4716 showed some activity at selected ERR subtypes, but researchers wanted a more potent compound that could activate ERR receptors simultaneously.1

This led to the development of SLUPP332, a small molecule that could activate ERR(alpha), ERR(beta), and ERRy simultaneously, with the greatest activity noticed at ERRα.1 This initial research was conducted by lead researchers Thomas P. Burris, Bahaa Elgendy, and Cyrielle Billon, who were affiliated with Saint Louis University (SLU).1

The “SLU” prefix in the compound stands directly for Saint Louis University.

Why Researchers Study SLU-PP-332

ERRs regulate genes involved in mitochondrial function, cellular energy homeostasis, and oxidative metabolism. While ERRs are structurally related to estrogen, they don’t need estrogen for activation, and they instead regulate distinct metabolic pathways.2

As such, researchers study SLUPP332 in the following areas:

• Estrogen-related receptor pharmacology
• Nuclear receptor signaling
• Gene transcription
• Mitochondrial biogenesis
• Oxidative phosphorylation
• Cellular energy metabolism
• Skeletal muscle cell biology
• Structure-activity relationship studies
• Small-molecule agonist development

Estrogen-Related Receptor Activation – SLU PP 332 is a pan-agonist of ERRs, meaning it activates all three receptor subtypes (ERRα, ERRβ, and ERRγ). Researchers continue to study how this compound interacts with these ERR receptors, including the activity it demonstrates in each receptor subtype.

Transcriptional Regulation – Because SLU PP 332 directly activates ERRs, it’s become important for studying transcriptional regulation. ERRs function within the cell nucleus, unlike receptors located on the cell surface. Once activated, they bind specific DNA response elements and regulate transcription of genes involved in cellular metabolism. Researchers continue to study this process to understand how nuclear receptor signaling coordinates metabolism in different tissues.2

PGC-1(alpha) and Mitochondrial Biology – One of the most widely studied partners of ERR signaling is peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1(alpha) ). Simply put, PGC-1(alpha) is a transcriptional coactivator that enhances ERR-mediated gene expression. Together, these proteins regulate numerous genes associated with mitochondrial biology, oxidative phosphorylation, and cellular respiration.³ Researchers frequently investigate SLU-PP-332 within this broader signaling network to better understand how transcriptional regulators are involved in mitochondrial function.

SLU-PP-332 Compared With Related ERR Agonists

SLU-PP-332 belongs to a growing family of experimental compounds developed to investigate estrogen-related receptor biology.

Researchers interested in metabolic signaling compounds may also wish to explore our broader catalog of peptide blends.

Important Notice – We supply SLU-PP-332 exclusively for research. It’s not approved for human or veterinary use. Any discussion concerning the biological activity of SLU-PP-332 refers to preclinical and in vitro studies only.

References

1. Billon C, Sitaula S, Banerjee S, et al. Synthetic ERRa/b/y/ agonist induces an ERR(alpha)-dependent acute aerobic exercise response and enhances exercise capacity. ACS Chem Biol. 2023;18(4):756-771. doi:10.1021/acschembio.2c00720

2. Giguère V. Transcriptional control of energy homeostasis by the estrogen-related receptors. Endocr Rev. 2008;29(6):677-696. doi:10.1210/er.2008-0017

3. Villena JA, Kralli A. ERR(alpha): a metabolic function for the oldest orphan. Trends Endocrinol Metab. 2008;19(8):269-276. doi:10.1016/j.tem.2008.07.005

When you’re studying a novel compound like SLU-PP-332, quality and transparency are important. Because this compound has only recently entered the research landscape, researchers need confidence that it’s independently verified and manufactured to consistent standards.

Here at Licensed PeptidesTM, every batch of SLU-PP-332 that we supply follows a strict, pharma-grade workflow, ensuring the compound you purchase is stable and pure, from synthesis to delivery.

What Sets Us Apart

How orders ship

We understand that timing and product integrity are critical for research.

How orders are handled

Delivery times

Shipping times are estimates and begin after order processing. Delays may occur due to carrier issues, weather, or other unforeseen factors, and delivery dates are not guaranteed. Full terms are in our Shipping & Delivery Policy.