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Overview
Tesamorelin
Tesamorelin (hyperlink to Tesamorelin page) is a synthetic peptide analog of growth hormone–releasing hormone (GHRH). After administration, it binds to GHRH receptors on somatotroph cells in the anterior pituitary gland. This receptor activation stimulates intracellular signaling pathways, which in turn enhance the synthesis and secretion of endogenous growth hormone. The increased growth hormone then acts primarily on the liver and other peripheral tissues to stimulate the production of insulin-like growth factor-1 (IGF-1), which mediates many of the downstream metabolic effects.
Through the combined actions of growth hormone and IGF-1, Tesamorelin promotes lipolysis and preferentially reduces visceral adipose tissue, while having minimal impact on subcutaneous fat. It also improves lipid metabolism, with documented reductions in triglycerides and non-HDL cholesterol. However, because of its stimulation of growth hormone pathways, Tesamorelin can influence glucose metabolism, which is clinically relevant in patients with or at risk of diabetes.
In summary, Tesamorelin exerts its effects by mimicking natural GHRH to increase growth hormone and IGF-1 levels, ultimately leading to a targeted reduction in visceral fat and improvements in metabolic parameters.
Ipamorelin
Ipamorelin (hyperlink to Ipamorelin page) is a synthetic pentapeptide that functions as a selective growth hormone secretagogue. It belongs to the class of ghrelin mimetics, often referred to as growth hormone–releasing peptides (GHRPs). After administration, Ipamorelin binds to and activates the ghrelin receptor, also known as the growth hormone secretagogue receptor (GHSR-1a), located on pituitary somatotroph cells as well as in the hypothalamus.
This receptor activation stimulates the release of endogenous growth hormone in a pulsatile manner, mimicking the body’s natural rhythm. Unlike some earlier GHRPs, such as GHRP-6 or hexarelin, Ipamorelin is highly selective: it triggers GH release without significantly affecting other pituitary hormones like prolactin, cortisol, or ACTH.
Once growth hormone is released, it acts on the liver and peripheral tissues to increase production of insulin-like growth factor-1 (IGF-1). IGF-1 mediates many of the anabolic and metabolic effects of GH, including enhanced protein synthesis, increased muscle growth, improved tissue repair, and stimulation of lipolysis.
Because of its receptor selectivity and clean profile, Ipamorelin produces a physiological rise in GH and IGF-1 levels with fewer off-target effects. This makes it a well-tolerated GH secretagogue that supports lean muscle development, fat metabolism, and recovery processes, while minimizing unwanted endocrine disturbances.
Scientific Journal & Authors
Dr. Beck is cited as one of the key researchers involved in the study and development of ipamorelin. This reference does not imply that he supports, promotes, or recommends the purchase, sale, or use of this compound in any way. There is no connection, endorsement, or relationship, explicit or implied, between Licensed Peptides and Dr. Beck.
Referenced Citations
A New Series of Highly Potent Growth Hormone-Releasing Peptides Derived from Ipamorelin
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The products available on this website are intended solely for in-vitro research purposes (Latin: “in glass”), meaning they are used in experiments conducted outside a living organism. These products are not medicines or drugs, have not been evaluated or approved by the U.S. Food and Drug Administration (FDA), and are not intended to diagnose, treat, cure, or prevent any disease or medical condition. Any administration to humans or animals, whether by ingestion, injection, or other means, is strictly prohibited by law.
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Storage Instructions:
All of our products are manufactured using the Lyophilization (Freeze Drying) process, which ensures that our products remain 100% stable for shipping for up to 3-4 months.
Once the peptides are reconstituted (mixed with bacteriostatic water), they must be stored in the fridge to maintain stability. After reconstitution, the peptides will remain stable for up to 30 days.
Lyophilization is a unique dehydration process, also known as cryodesiccation, where the peptides are frozen and then subjected to low pressure. This causes the water in the peptide vial to sublimate directly from solid to gas, leaving behind a stable, crystalline white structure known as lyophilized peptide. The puffy white powder can be stored at room temperature until you’re ready to reconstitute it with bacteriostatic water.
Once peptides have been received, it is imperative that they are kept cold and away from light. If the peptides will be used immediately, or in the next several days, weeks or months, short-term refrigeration under 4C (39F) is generally acceptable. Lyophilized peptides are usually stable at room temperatures for several weeks or more, so if they will be utilized within weeks or months such storage is typically adequate.
However, for longer term storage (several months to years) it is more preferable to store peptides in a freezer at -80C (-112F). When storing peptides for months or even years, freezing is optimal in order to preserve the peptide’s stability.
For further information on proper storage techniques, click the link below: