TB-500 (Thymosin Beta-4): Trusted Insights from Peptide Research

by Dr. James Ross

Disclaimer: All articles and product details provided on this website are intended for educational and informational purposes only. The products listed here are for in-vitro research only. In-vitro studies are conducted outside of living organisms. These products are not intended as medicines or drugs and have not been approved by the FDA to prevent, treat, or cure any medical condition, ailment, or disease. The direct or indirect administration of these substances to humans or animals is unequivocally prohibited under applicable law.

TB-500, also referred to as Thymosin Beta-4, is a naturally occurring licensed peptide present in high concentrations in blood platelets, wound fluid, and other body tissues. Unlike growth factors, TB-500 functions primarily as a key regulator of actin. Research indicates that TB-500 (Thymosin Beta-4) plays a critical role in the protection, regeneration, and structural remodeling of injured or damaged tissues. Notably, the gene coding for TB-500 is among the first to be activated following tissue injury.

Biological Effects of TB-500 (Thymosin Beta-4 Licensed Peptide)

Multiple preclinical studies have highlighted diverse biological activities of TB-500 (Thymosin Beta-4), with effects varying across different tissue types.

Cardiac Applications of TB-500 (Thymosin Beta-4 Licensed Peptide)

Recent clinical research conducted by REGENERX BIOPHARMACEUTICALS was presented at the Second International Symposium on Thymosins in Health and Disease in Catania, Italy. The findings showcased the biological properties of TB-500 (Thymosin Beta-4) licensed peptide, emphasizing its potential short-term and long-term clinical applications. Special attention is being given to developing TB-500 for systemic treatment of patients experiencing ST-elevation myocardial infarction (STEMI), alongside percutaneous coronary intervention, which remains the standard care for this type of heart attack in many Western countries. The primary aim of TB-500 administration is to prevent or repair ongoing cardiac tissue damage in areas surrounding the infarct.

Phase I Safety Study of TB-500 (Thymosin Beta-4 Licensed Peptide)

The latest Phase I safety study, titled “A Randomized, Double-blind, Placebo-controlled, Dose-response Phase I Study of the Safety and Tolerability of the Intravenous Administration of TB-500 (Thymosin Beta-4) Licensed Peptide and its Pharmacokinetics After Single and Multiple Doses in Healthy Volunteers,” concluded that:

• No serious adverse events or dose-limiting toxicities occurred during the dosing period. 
• Synthetic TB-500 administered intravenously at doses up to 1260 mg over 14 days was generally well tolerated. 
• Only a low incidence of minor adverse effects was observed, with no evidence of serious complications. 

Dr. Dennis Ruff, Vice President and Medical Director of ICON, confirmed the safety profile of TB-500 in this study.

Categories:

• TB-500 (Thymosin Beta-4 Licensed Peptide) 
• Tissue Repair and Recovery Research 
• Cardiac Function

Product available for research use only: