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FOXO4-DRI · 10mg
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GMP-Certified Manufacturing — USA facility, ISO 9001:2015
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Lyophilized for Stability — Shipped cold-packed, intact for reconstitution
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Third Party Tested
APPLICATION
For Research Use only
Form
Lyophilized Powder
Storage
-20°C Long Term
Purity (HPLC)
99%+ Third Party Verified
Manufacture
USA / GMP
4.9 847 verified reviews
FOXO4-DRI · 10mg
Total Price
$599.97
Discounted Price
$497.97
Vials
3 vials
You Save
$102.00
17% OFF
Select Strength (mg)
99% HPLC Purity
Select Vials
Bulk pricing applied
📈 Upgrade to 10 vials and save an extra vs. buying 5 — nearly 3 free vials.
Select Purchase Option:
-
99%+ HPLC Purity —
Independently verified by accredited US laboratory
-
Endotoxin-Screened —
LAL tested, LPS-free, endotoxin report available
-
GMP-Certified Manufacturing —
USA facility, ISO 9001:2015
-
Lyophilized for Stability —
Shipped cold-packed, intact for reconstitution
Molecular Weight
Third Party Tested
APPLICATION
For Research Use only
Form
Lyophilized Powder
Storage
-20°C Long Term
Purity (HPLC)
99%+ Third Party Verified
Manufacture
USA / GMP
FOXO4-DRI (FOXO4-D-Retro-Inverso) is a synthetic senolytic research peptide designed to interfere with the interaction between the transcription factor FOXO4 and the tumor-suppressor protein p53. This interaction is associated with the survival of senescent cells. By disrupting the FOXO4–p53 interaction, FOXO4-DRI has been investigated for its ability to promote apoptosis, or programmed cell death, in selected senescent-cell models.
FOXO4-DRI at a glance
| Molecular formula | C228H388N86O64 |
|---|---|
| Molecular weight | 5,358.06 g/mol |
| CAS number | 2460055-10-9 |
| Application | Research use only |
What is FOXO4-DRI?
FOXO4-DRI is a synthetic D-retro-inverso (DRI) peptide developed as a research tool for investigating the molecular mechanisms underlying cellular senescence. The peptide is derived from a region of the FOXO4 forkhead domain and was designed to interfere with the interaction between FOXO4 and the tumor-suppressor protein p53, a protein-protein interaction that has been implicated in the survival of senescent cells.
In preclinical research, FOXO4-DRI has been studied for its potential senolytic activity, referring to the selective targeting and removal of certain senescent cells. Experimental studies suggest that FOXO4-DRI competes with endogenous FOXO4 for binding to p53. This disruption can promote the redistribution of activated p53 away from the nucleus and contribute to the activation of apoptosis-related pathways in susceptible senescent cells.
Research involving cultured human cells has reported that FOXO4-DRI can reduce the viability of selected senescent cell populations while showing comparatively less effect on non-senescent cells under certain experimental conditions. Studies have investigated its activity in several cellular models, including fibroblasts and chondrocytes, providing researchers with a tool for examining the relationship between cellular senescence, p53 signaling, and programmed cell death.
Why is FOXO4-DRI studied?
The peptide was designed as a chemical probe of the FOXO4–p53 interaction, which had been identified as a node in senescent cells; a proteolysis-resistant competitor was needed to test whether disrupting that interaction would change the fate of those cells.2
How is FOXO4-DRI studied in the lab?
Reported laboratory work used senescent cell cultures with viability and apoptosis readouts, immunoprecipitation to confirm disruption of the FOXO4–p53 complex, and mouse models of chemotoxicity and ageing.2
What has preclinical research reported?
Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging
This is the foundational study associated with FOXO4-DRI. The researchers investigated the FOXO4–p53 interaction and developed an all-D-amino-acid peptide designed to disrupt this interaction. In cellular and mouse models, FOXO4-DRI was investigated for its ability to induce apoptosis in senescent cells and improve selected measures of tissue homeostasis.
Structural plasticity of the FOXO-DBD:p53-TAD interaction
This study provides additional structural insight into the FOXO4–p53 interaction, which is directly relevant to understanding the molecular basis of FOXO4-DRI activity. It focuses on the structural flexibility and interaction between FOXO proteins and the p53 transactivation domain.
Senescent-cell models
Baar and colleagues reported that a FOXO4-based retro-inverso peptide caused targeted apoptosis of senescent cells in culture and altered tissue readouts in mouse models of chemotoxicity and ageing.2
Forms studied and handling
Supplied as a lyophilised powder. Store as stated in the specification box above, protected from light and moisture, and keep the vial sealed until use.
References
- Krimpenfort, P., & Berns, A. (2017). Rejuvenation by Therapeutic Elimination of Senescent Cells. Cell, 169(1), 3–5. https://doi.org/10.1016/j.cell.2017.03.014. PMID 28340347
- Baar MP, Brandt RMC, Putavet DA, et al. Targeted apoptosis of senescent cells restores tissue homeostasis in response to chemotoxicity and aging. Cell. 2017;169(1):132–147.e16. doi:10.1016/j.cell.2017.02.031
For laboratory research use only. Products on this website are intended solely for in-vitro research. They are not medicines, have not been evaluated by the FDA, and are not intended to diagnose, treat, cure, or prevent any disease. Any administration to humans or animals is strictly prohibited.
What are these peptides made for?
Our peptides are produced exclusively for laboratory and scientific research purposes.
Licensed Peptides™ products are developed using industry-standard synthesis and purification protocols, making them suitable for in vitro research, analytical testing, and experimental models.
Research-grade standards
- Synthesized via Solid Phase Peptide Synthesis (SPPS)
- Purified using advanced HPLC methods
- Verified through analytical quality control processes
- Screened for heavy metals and endotoxins
Consistency across batches
Strict process controls ensure reproducibility, allowing researchers to work with confidence across experiments.
Applications
Our peptides are commonly used in research involving:
- Cellular signaling pathways
- Tissue remodeling and repair mechanisms
- Extracellular matrix regulation
- Molecular biology and biochemical studies
All products are intended for research use only and are not for human or animal consumption, therapeutic use, or clinical application.
Why buy from Licensed Peptides
At Licensed Peptides™, quality isn’t a claim — it’s a controlled, repeatable process.
Every peptide we produce follows a strict, pharma-grade workflow designed to ensure purity, stability, and consistency from synthesis to delivery.
What sets us apart
ISO-certified cleanroom manufacturing
All peptides are synthesized in sterile, controlled environments to eliminate contamination risk and ensure batch consistency.
>99% verified purity (HPLC tested)
We use advanced High-Performance Liquid Chromatography (HPLC) to separate and verify peptide purity with precision.
Comprehensive safety testing
Each batch undergoes heavy metal and endotoxin screening to ensure it is free from hidden contaminants.
Pharma-grade raw materials
We start with rigorously tested amino acids and reagents, ensuring integrity at the molecular level.
Lyophilized for stability
Freeze-dried peptides maintain long-term stability, potency, and reliability for research applications.
Nitrogen-sealed vials
Every vial is protected from oxygen and moisture, preserving structural integrity during storage and transit.
Built for serious research
From synthesis to delivery, every step is engineered to meet the expectations of professionals who require accuracy, consistency, and reliability.
For laboratory research use only. Not for human or veterinary use.
How orders ship
We understand that timing and product integrity are critical for research.
| Ships to | United States (including minor outlying islands) |
|---|---|
| Processing days | Monday to Friday, excluding holidays |
| Daily cut-off | Paid orders placed before 4:00 PM PST are typically shipped the same business day |
| Free shipping | FedEx 2-Day Express on orders over $200 and for VIP members |
| Standard | USPS Ground Advantage, 3–7 business days (not guaranteed) — $8.95 |
| Expedited | FedEx 2-Day $11.95 · UPS 2-Day $19.95 · FedEx Next Day $44.99 |
| Signature | Required on delivery for orders of $1,000 or more |
How orders are handled
Cold chain protection
Products are stored in industrial-grade freezers prior to shipment to maintain stability and purity.
Secure & protective packaging
Each order is carefully packed to protect against temperature fluctuations, moisture exposure, and physical damage during transit.
Tracking
Once your order has shipped you will receive a tracking number by email, so you can monitor delivery progress.
Shipped from the United States
Orders are dispatched domestically from a U.S.-based operation, so there are no international customs steps.
Delivery times
Shipping times are estimates and begin after order processing. Delays may occur due to carrier issues, weather, or other unforeseen factors, and delivery dates are not guaranteed. Full terms are in our Shipping & Delivery Policy.
For laboratory research use only. Not for human or veterinary use.
Storage conditions at a glance
| Lyophilized, in transit | Stable for shipping for up to 3–4 months |
|---|---|
| Lyophilized, short term | Room temperature is usually adequate for several weeks; refrigeration under 4°C (39°F) is generally acceptable |
| Lyophilized, long term | Freezer at -80°C (-112°F) for several months to years |
| After reconstitution | Refrigerated; stable for up to 30 days |
| Light and moisture | Keep cold and away from light in the original sealed vial |
Why the powder is stable
All of our products are manufactured using the lyophilization (freeze drying) process, which keeps them stable for shipping for up to 3–4 months.
Lyophilization is a unique dehydration process, also known as cryodesiccation, where the peptides are frozen and then subjected to low pressure. This causes the water in the peptide vial to sublimate directly from solid to gas, leaving behind a stable, crystalline white structure known as lyophilized peptide. The puffy white powder can be stored at room temperature until it is reconstituted with bacteriostatic water.
Storing vials on arrival
Once peptides have been received, it is imperative that they are kept cold and away from light. If the peptides will be used in the next several days, weeks or months, short-term refrigeration under 4°C (39°F) is generally acceptable. Lyophilized peptides are usually stable at room temperatures for several weeks or more, so if they will be utilized within weeks or months such storage is typically adequate.
For longer term storage (several months to years) it is more preferable to store peptides in a freezer at -80°C (-112°F). When storing peptides for months or even years, freezing is optimal in order to preserve the peptide’s stability.
After reconstitution
Once the peptides are reconstituted with bacteriostatic water, they must be stored in the fridge to maintain stability. After reconstitution, the peptides will remain stable for up to 30 days.
For laboratory research use only. Not for human or veterinary use.
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