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MOTS-C
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99%+ HPLC Purity — Independently verified by accredited US laboratory -
Endotoxin-Screened — LAL tested, LPS-free, endotoxin report available
-
GMP-Certified Manufacturing — USA facility, ISO 9001:2015
-
Lyophilized for Stability — Shipped cold-packed, intact for reconstitution
Molecular Weight
Third Party Tested
APPLICATION
For Research Use only
Form
Lyophilized Powder
Storage
-20°C Long Term
Purity (HPLC)
99%+ Third Party Verified
Manufacture
USA / GMP
4.9 847 verified reviews
MOTS-C
Total Price
$775.79
Discounted Price
$449.96
Vials
10 vials
You Save
$325.83
42% OFF
Select Strength (mg)
99% HPLC Purity
Select Vials
Bulk pricing applied
📈 Upgrade to 10 vials and save an extra vs. buying 5 — nearly 3 free vials.
Select Purchase Option:
-
99%+ HPLC Purity —
Independently verified by accredited US laboratory
-
Endotoxin-Screened —
LAL tested, LPS-free, endotoxin report available
-
GMP-Certified Manufacturing —
USA facility, ISO 9001:2015
-
Lyophilized for Stability —
Shipped cold-packed, intact for reconstitution
Molecular Weight
Third Party Tested
APPLICATION
For Research Use only
Form
Lyophilized Powder
Storage
-20°C Long Term
Purity (HPLC)
99%+ Third Party Verified
Manufacture
USA / GMP
Licensed Peptides: MOTS-C Peptide
-
- ISO-certified cleanroom manufacturing
- 99%+ verified purity through HPLC analysis
- Comprehensive batch testing and analytical verification
- Lyophilized for stability during storage and transport
- Batch-specific Certificates of Analysis available
What Is MOTS-C?
MOTS-C is a mitochondrial-encoded peptide that originates from mitochondrial DNA. Unlike many signaling molecules made from nuclear genes, MOTS-C is encoded by the mitochondrial genome.¹
MOTS-C has attracted interest because of its involvement in mitochondrial signaling and cell-to-cell communication pathways.¹² Researchers are still investigating mitochondrion-derived peptides’ roles in broader biological signaling pathways.²³
Why Researchers Study MOTS-C
In a landmark study in Cell Metabolism, Lee and colleagues identified MOTS-C as a mitochondrial-derived peptide. They also reported on its role in cellular metabolic regulation. They found that it supports adaptive stress-response pathways in experimental models.¹
Later research by Kim and others showed that MOTS-C may move into the nucleus. This can happen during certain types of metabolic stress. The authors suggested that this process may support communication between mitochondria and the nucleus. It may also affect gene regulation within cells.²
Current research looks at these mechanisms in lab and preclinical models. However, there are still gaps in understanding how they work in humans.³
Mitochondrial Biology Research
One of the most distinctive characteristics of MOTS-C is its mitochondrial origin.¹
Mitochondrial-derived peptides may act as signals between mitochondria and the nucleus. They may help cells adapt under experimental conditions.²,³
Cellular Signaling Research
Investigations have examined MOTS-C within experimental models that evaluate cellular communication systems. The published studies have explored intracellular signaling pathways and nuclear translocation mechanisms. They also examined gene-regulatory activity and molecular communication networks. These factors may influence cellular adaptation responses.²,³
Current Research Limitations
Most published evidence on MOTS-C originates from laboratory and preclinical animal studies.³⁴ Large human clinical trials haven’t been published in peer-reviewed journals. These trials are still needed to confirm MOTS-C’s safety, efficacy, or therapeutic uses.³⁴
As a result, MOTS-C is a research compound exclusively for scientific investigation. Ongoing studies continue to evaluate its biological mechanisms, signaling pathways, and potential relevance within experimental research settings.³⁴
References
• Lee C, Zeng J, Drew BG, Sallam T, Martin-Montalvo A, Wan J, et al. The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance. Cell Metabolism. 2015;21(3):443-454. doi:10.1016/j.cmet.2015.02.009.
• Kim KH, Son JM, Benayoun BA, Lee C. The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress. Cell Metabolism. 2018;28(3):516-524.e7. doi:10.1016/j.cmet.2018.06.008.
• Lu H, Tang S, Xue C, et al. MOTS-c: An Equal Player in Mitochondrial Function and Aging? Frontiers in Endocrinology. 2023;14:1120533. doi:10.3389/fendo.2023.1120533.
• ClinicalTrials.gov. A Study of CB4211 (MOTS-c) in Participants With Prediabetes and Overweight or Obesity (Phase 2a). Identifier: NCT07505745.
Important Notice
This product is supplied strictly for research use only. It is not approved or intended for human or animal use, consumption, therapeutic use, clinical application, or diagnostic purposes. Any discussion of biological activity refers solely to laboratory, in vitro, or preclinical research.
MOTS-C at a glance
| Sequence | Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg |
|---|---|
| Molecular formula | C₁₀₁H₁₅₂N₂₈O₂₂S₂ |
| Molecular weight | 2174.64 g/mol |
| CAS number | 1627580-64-6 |
| PubChem CID | 255386757 |
| Application | Research use only |
What is MOTS-C?
MOTS-C is a mitochondrial-derived peptide encoded within the mitochondrial genome and studied in laboratory settings for its role in cellular signaling and metabolic regulation pathways. Research models examine how mitochondrial peptides interact with nuclear gene expression and cellular adaptation mechanisms. These references are provided solely to describe areas of scientific investigation and do not imply therapeutic, diagnostic, or clinical use. This product is supplied strictly for research purposes only.
Why is MOTS-C studied?
MOTS-C was first characterised in 2015 as one of a small family of peptides encoded by the mitochondrial genome rather than the nuclear genome. In research models it is studied as a tool compound for investigating how mitochondria communicate metabolic state to the nucleus. References to insulin sensitivity, adipose tissue or exercise physiology below are drawn from published literature and describe how the compound is studied, not an outcome for any individual.
How is MOTS-C studied in the lab?
In laboratory research, MOTS-C is examined for its interaction with mitochondrial signaling networks and cellular stress-response pathways. Experimental studies explore how mitochondrial peptides influence cellular energy regulation systems and gene transcription processes. All references to biological mechanisms are included solely for research context and should not be interpreted as claims of medical benefit.
What has preclinical research reported?
Research Areas
MOTS-C is used in experimental research investigating:
- mitochondrial-to-nuclear signaling mechanisms
- cellular stress-response pathways
- metabolic pathway regulation in experimental models
- mitochondrial peptide signaling dynamics
- gene transcription responses associated with cellular energy systems
All references to biological pathways are provided for research context only and do not imply human or veterinary applications.
Who publishes on MOTS-C?
Published literature describes MOTS-C in controlled experimental settings, including rodent metabolic models and cell culture. Those observations are summarised here as research context only. They are not claims of safety, effectiveness or suitability for human or veterinary use.
Research Focus: Metabolic Regulation – Cell and Rodent Models
Title: The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance (Cell Metabolism, 2015)
Authors: Changhan Lee, Jennifer Zeng, Brian G. Drew et al.
Research Focus: Exercise Physiology and Age-Dependent Decline
Title: MOTS-c is an Exercise-Induced Mitochondrial-Encoded Regulator of Age-Dependent Physical Decline and Muscle Homeostasis (Nature Communications, 2021)
Authors: Joseph C. Reynolds, Rebecca W. Lai, Jonathan S. T. Woodhead et al.
Research Focus: Ageing Biomarkers
Title: Naturally Occurring Mitochondrial-Derived Peptides are Age-Dependent Regulators of Apoptosis, Insulin Sensitivity and Inflammatory Markers (Aging, 2016)
Authors: Laura J. Cobb, Changhan Lee, Jialin Xiao et al.
References
- Yu WD, Kim YJ, Cho MJ, Seok J, Kim GJ, Lee CH, Ko JJ, Kim YS, Lee JH. The mitochondrial-derived peptide MOTS-c promotes homeostasis in aged human placenta-derived mesenchymal stem cells in vitro. Mitochondrion. 2021 May;58:135-146. doi: 10.1016/j.mito.2021.02.010. Epub 2021 Feb 24. PMID: 33639272. PMID 33639272
- Crescenzo R, Bianco F, Mazzoli A, Giacco A, Liverini G, Iossa S. A possible link between hepatic mitochondrial dysfunction and diet-induced insulin resistance. Eur J Nutr. 2016 Feb;55(1):1-6. doi: 10.1007/s00394-015-1073-0. PMID: 26476631. PMID 26476631
- Mohtashami Z, Singh MK, Salimiaghdam N, Ozgul M, Kenney MC. MOTS-c, the Most Recent Mitochondrial Derived Peptide in Human Aging and Age-Related Diseases. Int J Mol Sci. 2022 Oct 9;23(19):11991. doi: 10.3390/ijms231911991. PMID: 36233287; PMCID: PMC9570330. PMID 36233287
- doi:10.1016/j.cmet.2015.02.009
- doi:10.1038/s41467-020-20790-0
- doi:10.18632/aging.100943
For laboratory research use only. Products on this website are intended solely for in-vitro research. They are not medicines, have not been evaluated by the FDA, and are not intended to diagnose, treat, cure, or prevent any disease. Any administration to humans or animals is strictly prohibited.
Proper storage of MOTS-C is essential for maintaining peptide stability and quality throughout laboratory use. Licensed Peptides manufactures all research peptides using the lyophilization process, which helps support stability during shipping and laboratory handling.
Understanding Lyophilization
MOTS-C is supplied as a lyophilized peptide powder.
Lyophilization, also called ‘freeze-drying’ or ‘cryodesiccation’, is a dehydration process. In this process, peptides are first frozen and then exposed to low pressure. During this process, water is removed through sublimation, transitioning directly from a solid state to a gas.
This process leaves behind a stable, crystalline peptide structure that supports long-term storage and handling requirements. The resulting white lyophilized powder may remain stable for extended periods when stored under appropriate laboratory conditions.
Because moisture is removed during manufacturing, lyophilized peptides are generally more stable during transportation and storage than reconstituted peptide preparations.
After Reconstitution
Once MOTS-C has been reconstituted using bacteriostatic water for laboratory purposes, it should be refrigerated and protected from excessive heat and light exposure.
Researchers should monitor all preparations for changes in appearance and discard any material exhibiting cloudiness, discoloration, or particulate formation.
Recommended Storage Conditions
Short-Term Storage
- Refrigeration below 4°C (39°F) is generally recommended.
- Protect from direct sunlight, heat, and excessive moisture.
- Lyophilized peptides may remain stable at room temperature for limited periods when intended for near-term laboratory use.
Long-Term Storage
- Freezer storage is recommended for extended preservation.
- For multi-month or multi-year storage, temperatures of -80°C (-112°F) are generally considered optimal for maintaining peptide stability.
- Avoid repeated freeze-thaw cycles whenever possible.
Research Storage Best Practices
Researchers should maintain consistent storage conditions throughout the lifecycle of the peptide. Temperature fluctuations, moisture exposure, and repeated handling may affect long-term stability.
For additional handling recommendations, storage procedures, and laboratory best practices, please refer to our Peptide Storage Guide.
For laboratory research use only. Not for human or veterinary use.
To support reproducible scientific research, every MOTS-C batch is manufactured and verified according to strict quality-control procedures. MOTS-C is synthesized using Solid-Phase Peptide Synthesis (SPPS), a widely used peptide manufacturing method that supports precise amino acid sequencing and batch-to-batch consistency.
Analytical Verification
Each batch undergoes extensive testing, which may include:
- High-Performance Liquid Chromatography (HPLC) purity analysis
- Identity verification
- Batch consistency assessment
- Contaminant screening
- Manufacturing quality review
Manufacturing Standards
Licensed Peptides utilizes controlled manufacturing environments and established peptide synthesis protocols designed to promote consistency across production batches.
Researchers receive access to batch-specific documentation that supports transparency and traceability throughout the procurement process.
For laboratory research use only. Not for human or veterinary use.
Quality assurance is central to our manufacturing philosophy.
ISO-Certified Cleanroom Manufacturing
All peptides are synthesized within controlled manufacturing environments to minimize contamination risks and support batch consistency.
99%+ Verified Purity
Every MOTS-C batch undergoes analytical purity verification using advanced HPLC testing methods. Read more about how peptides are purified.
Comprehensive Batch Testing
Testing protocols verify product identity, purity, and overall quality.
Pharma-Grade Raw Materials
We begin with carefully sourced raw materials that undergo quality review before entering production.
Lyophilized For Stability
Our peptides are supplied in a freeze-dried format that supports long-term stability and laboratory handling.
Nitrogen-Sealed Vials
Each vial is protected from moisture and oxygen exposure to help preserve peptide integrity during storage and transit.
For laboratory research use only. Not for human or veterinary use.
We understand that timing and product integrity are critical for scientific research, so we process every MOTS-C order using established fulfillment procedures. These steps support reliable delivery and help maintain product quality during transit.
Same-Day Shipping (USA)
Paid, in-stock orders placed before our 4:00 PM PST cut-off are typically shipped the same business day from within the United States.
Expedited domestic carriers
We use expedited domestic carriers for delivery within the United States. Shipping times are estimates and delivery dates are not guaranteed.
Cold Storage & Product Protection
Before shipment, MOTS-C is stored under controlled conditions maintain peptide stability and quality. Products remain protected until they enter the fulfillment process.
Secure & Protective Packaging
We package each order carefully to help protect against physical damage, moisture exposure, and environmental fluctuations during transit.
Real-Time Tracking
We provide tracking information immediately after shipment, allowing researchers to monitor delivery progress from dispatch through arrival.
Batch Documentation Available
Supporting quality documentation, including batch-specific Certificates of Analysis (COAs), is available to provide transparency regarding purity, identity verification, and analytical testing standards.
Consistency You Can Rely On
Our fulfillment process provides dependable domestic delivery without extended international shipping delays or customs-related disruptions. Researchers can expect reliable order processing, transparent tracking, and responsive U.S.-based support.
Research-First Fulfillment
Every stage of the process, from manufacturing through delivery, supports researchers who require consistency, traceability, and quality assurance when sourcing research materials.
For laboratory research use only. Not for human or veterinary use.
Additional information
| pack | 1 pack, 3 pack, 5 pack, 10 pack |
|---|
99%+ — Passes ≥99% 
Download Full COA / HPLC Report (PDF) 
99%+ Every Batch
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