Pinealon · 10mg

What is Pinealon?

Pinealon is a laboratory research material used to examine peptide behavior, intracellular signaling, and cellular-response pathways in controlled experimental models. References to biological effects are provided for scientific context only and must not be interpreted as claims of therapeutic, diagnostic, or clinical benefit. This product is not offered for human or veterinary use.

Pinealon is a synthetic short peptide of the Khavinson bioregulator series, supplied as a lyophilised solid. Peptides of this length are studied as defined chemical entities rather than as extracts: their sequence, molecular weight and solubility are fixed, which makes them convenient reference compounds in cell-free and cell-culture work.⁴

Why is Pinealon studied?

Laboratory interest in this peptide class comes from reports that very short peptides can enter cells and interact with double-stranded DNA, a property examined systematically by structural and computational screening of peptide-DNA binding motifs.⁵ That work positions short peptides as tools for studying sequence-selective nucleic-acid interaction.⁶

How is Pinealon studied in the lab?

In laboratory research, Pinealon is examined for its interaction with cellular systems and downstream pathway responses. Experimental studies explore how short peptides may influence gene-expression patterns, cellular adaptation, and molecular signaling in controlled research environments. All references to biological mechanisms are included solely for research context and should not be interpreted as claims of medical benefit.

Published studies in this area use cultured cells, cell-free DNA binding assays and molecular modelling. Endpoints are typically peptide uptake into the cell and nucleus, binding affinity and selectivity for defined DNA sequences, and downstream transcript levels measured by PCR.^{4, 5}

What has preclinical research reported?

Forms studied and handling

Supplied as a lyophilised powder in a sealed vial. Published handling practice for research peptides of this class is cold, dry, light-protected storage of the lyophilised solid, with reconstituted material kept refrigerated and used within the stability window established by the laboratory. For laboratory research use only.

References

1. Fedoreyeva, L. I., Kireev, I. I., Khavinson, V. K.h, & Vanyushin, B. F. (2011). Penetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNA. Biochemistry. Biokhimiia, 76(11), 1210–1219. https://doi.org/10.1134/S0006297911110022. PMID 22117547
2. Meshchaninov, V. N., Tkachenko, E. L., Zharkov, S. V., Gavrilov, I. V., & Katyreva, I.uE. (2015). Advances in gerontology = Uspekhi gerontologii, 28(1), 62–67. PMID 26390612
3. Kozina L. S. (2008). Advances in gerontology = Uspekhi gerontologii, 21(1), 61–67. PMID 18546825
4. Khavinson VK, Solovyev AY, Tarnovskaya SI, et al. Mechanism of biological activity of short peptides: cell penetration and epigenetic regulation of gene expression. Biol Bull Rev. 2013;3(6):451-455. doi:10.1134/S2079086413060042
5. Kolchina N, Khavinson V, Linkova N, et al. Systematic search for structural motifs of peptide binding to double-stranded DNA. Nucleic Acids Res. 2019;47(20):10553-10563. doi:10.1093/nar/gkz850
6. Khavinson VK, Linkova NS, Tarnovskaya SI. Short peptides regulate gene expression. Bull Exp Biol Med. 2016;162(2):288-292. doi:10.1007/s10517-016-3596-7